1887

Abstract

This study attempted to determine whether cefuroxime was superior to cephalothin as a surrogate marker for cefpodoxime among urinary tract isolates. The MicroScan system (Siemens) was used to determine susceptibility for cephalothin and cefuroxime on consecutive cultures with a colony count of ≥50 000 organisms. Simultaneously, an Etest (bioMérieux) for cefpodoxime was conducted. The cefpodoxime interpretation was compared to that of the other two agents, and the categorical agreement was calculated, defined as the percentage of identical susceptibility interpretations. Cefuroxime (83 %) had a significantly higher categorical agreement than cephalothin (63 %) among 300 isolates 0.01). The major error rate was 16 % for cephalothin and 3 % for cefuroxime. The very major error rate was 7 % for cephalothin and 14 % for cefuroxime among the 14 cefpodoxime-resistant isolates. For , the major error rates were 15 % and 1 % for cephalothin and cefuroxime, respectively. Very major error rates were 9 % for both agents. Cefuroxime was a better predictor of cefpodoxime susceptibility than cephalothin, and appears to be the preferred surrogate agent for the MicroScan system, particularly for .

Loading

Article metrics loading...

/content/journal/jmm/10.1099/jmm.0.063040-0
2014-02-01
2024-03-29
Loading full text...

Full text loading...

/deliver/fulltext/jmm/63/2/218.html?itemId=/content/journal/jmm/10.1099/jmm.0.063040-0&mimeType=html&fmt=ahah

References

  1. Brown P. D., Freeman A., Foxman B. 2002; Prevalence and predictors of trimethoprim-sulfamethoxazole resistance among uropathogenic Escherichia coli isolates in Michigan. Clin Infect Dis 34:1061–1066 [View Article][PubMed]
    [Google Scholar]
  2. CLSI 2013; Performance Standards for Antimicrobial Susceptibility Testing; 23rd Informational Supplement M100-S23. Wayne, PA: Clinical and Laboratory Standards Institute;
    [Google Scholar]
  3. Gottesman B. S., Carmeli Y., Shitrit P., Chowers M. 2009; Impact of quinolone restriction on resistance patterns of Escherichia coli isolated from urine by culture in a community setting. Clin Infect Dis 49:869–875 [View Article][PubMed]
    [Google Scholar]
  4. Gupta K., Hooton T. M., Naber K. G., Wullt B., Colgan R., Miller L. G., Moran G. J., Nicolle L. E., Raz R.& other authors ( 2011; International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women: a 2010 update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases. Clin Infect Dis 52:e103–e120 [View Article][PubMed]
    [Google Scholar]
  5. Hooton T. M., Roberts P. L., Stapleton A. E. 2012; Cefpodoxime vs ciprofloxacin for short-course treatment of acute uncomplicated cystitis: a randomized trial. JAMA 307:583–589 [View Article][PubMed]
    [Google Scholar]
  6. Johnson L., Sabel A., Burman W. J., Everhart R. M., Rome M., MacKenzie T. D., Rozwadowski J., Mehler P. S., Price C. S. 2008; Emergence of fluoroquinolone resistance in outpatient urinary Escherichia coli isolates. Am J Med 121:876–884 [View Article][PubMed]
    [Google Scholar]
  7. Kavatha D., Giamarellou H., Alexiou Z., Vlachogiannis N., Pentea S., Gozadinos T., Poulakou G., Hatzipapas A., Koratzanis G. 2003; Cefpodoxime-proxetil versus trimethoprim-sulfamethoxazole for short-term therapy of uncomplicated acute cystitis in women. Antimicrob Agents Chemother 47:897–900 [View Article][PubMed]
    [Google Scholar]
  8. Mehta S. A., Paperno Y., Allen A. K., Pullano P. P., Phillips M. 2011; Evaluating oral cephalosporins for outpatient therapy of UTI: susceptibility testing from a New York City emergency department. Presented at 21st Annual Scientific Meeting. Society for Healthcare Epidemiology of America, Dallas, Texas. Abstract 584
    [Google Scholar]
  9. Milo G., Katchman E. A., Paul M., Christiaens T., Baerheim A., Leibovici L. 2005; Duration of antibacterial treatment for uncomplicated urinary tract infection in women. Cochrane Database Sys Rev18
    [Google Scholar]
  10. Olson R. P., Harrell L. J., Kaye K. S. 2009; Antibiotic resistance in urinary isolates of Escherichia coli from college women with urinary tract infections. Antimicrob Agents Chemother 53:1285–1286 [View Article][PubMed]
    [Google Scholar]
  11. Product Information 2006 Nitrofurantoin Princeton, NJ: Sandoz;
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/jmm.0.063040-0
Loading
/content/journal/jmm/10.1099/jmm.0.063040-0
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error