RT Journal Article SR Electronic(1) A1 Murthy, Madhukiran H. A1 Olson, Michael E. A1 Wickert, Robert W. A1 Fey, Paul D. A1 Jalali, ZibaYR 2008 T1 Daptomycin non-susceptible meticillin-resistant Staphylococcus aureus USA 300 isolate JF Journal of Medical Microbiology, VO 57 IS 8 SP 1036 OP 1038 DO https://doi.org/10.1099/jmm.0.2008/000588-0 PB Microbiology Society, SN 1473-5644, AB Daptomycin is a novel bactericidal agent active against Gram-positive pathogens including meticillin-resistant Staphylococcus aureus (MRSA). Our case is unique in the description of an MRSA USA 300 isolate that developed decreased susceptibility to daptomycin during daptomycin and vancomycin therapy. Directed sequencing detected a previously reported mutation in mprF, resulting in a T345A substitution, associated with non-susceptibility to daptomycin., UL https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.2008/000588-0