@article{mbs:/content/journal/jmm/10.1099/jmm.0.2008/002428-0, author = "Brilhante, Raimunda S. N. and Cordeiro, Rossana A. and Rocha, Marcos F. G. and Fechine, Maria A. B. and Furtado, Felipe M. and Nagao-Dias, Aparecida T. and Camargo, Zoilo P. and Sidrim, José J. C.", title = "Coccidioidal pericarditis: a rapid presumptive diagnosis by an in-house antigen confirmed by mycological and molecular methods", journal= "Journal of Medical Microbiology", year = "2008", volume = "57", number = "10", pages = "1288-1292", doi = "https://doi.org/10.1099/jmm.0.2008/002428-0", url = "https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.2008/002428-0", publisher = "Microbiology Society", issn = "1473-5644", type = "Journal Article", abstract = "Coccidioidal pericarditis is a condition found in approximately 1–5 % of patients infected by Coccidioides species. It is associated with widely diverse clinical symptoms. This paper reports a case of coccidioidal pericarditis diagnosed by an in-house Coccidioides posadasii antigen and confirmed with mycological and molecular methods. From February to September 2005, the patient suffered from fever, weight loss, a non-productive cough, thoracic pain and tachycardia. He received a positive diagnosis of coccidioidal pericarditis only in October 2005. The macromorphological examination of the culture showed a whitish felt-like colony, which became brownish with age. Preparations in lactophenol cotton blue stain showed hyaline septate hyphae with fragmentation and thin arthroconidia-like structures. Pericardial fluid and sera samples were positive for Coccidioides antibodies by immunodiffusion and ELISA with a C. posadasii in-house antigen preparation. The C. posadasii identification was confirmed by nested PCR of the antigen 2/proline-rich antigen (Ag2/PRA) encoding gene.", }