1887

Journal of Medical Microbiology logo

Volume 57, Issue 11

Brain and lung metastasis of alveolar echinococcosis in a refugee from a hyperendemic area Free

Abstract

Alveolar echinococcosis (AE) of the liver with cerebral and pulmonary metastasis was diagnosed in a Tibetan monk who initially presented with severe headache to an emergency department in Germany. Multiple lesions with perifocal oedema and severe compression of the third ventricle were seen with computed tomography (CT) of the brain. Glioma or cerebral metastasis of a hitherto undiagnosed abdominal or pulmonary malignancy was suspected. CT scans of the lung and liver demonstrated further tumorous masses. Magnetic resonance imaging of the brain revealed the cystic nature of the cerebral lesions and the patient had a highly positive serology for AE. The echinococcal aetiology of the brain lesions was confirmed by PCR for this refugee from an area where two disease entities, AE and cystic echinococcosis, are hyperendemic.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): AE, alveolar echinococcosis , CE, cystic echinococcosis , CSF, cerebrospinal fluid , CT, computed tomography , EVD, external ventricular drain , MRI, magnetic resonance imaging and PET, positron-emission tomography
SGM
Loading

Article metrics loading...

/content/journal/jmm/10.1099/jmm.0.2008/002816-0
2008-11-01
2024-04-20
Loading full text...

Full text loading...

/deliver/fulltext/jmm/57/11/1420.html?itemId=/content/journal/jmm/10.1099/jmm.0.2008/002816-0&mimeType=html&fmt=ahah

References

  1. Algros M.-P., Majo F., Bresson-Hadni S., Koch S., Godard J., Cattin F., Delbosc B., Kantelip B. 2003; Intracerebral alveolar echinococcosis. Infection 31:63–65 [CrossRef]
     [Google Scholar]
  2. Ammann R. W., Eckert J. 1996; Cestodes. Echinococcus . Gastroenterol Clin North Am 25:655–689 [CrossRef]
     [Google Scholar]
  3. Aydin Y., Barlas O., Yolaş C., Aydin I. H., Ceviz A., Aladağ A., Ören D., Akdemir D. 1986; Alveolar hydatid disease of the brain. Report of four cases. J Neurosurg 65:115–119 [CrossRef]
     [Google Scholar]
  4. Barjhoux P., Gilbertas A., Girona G. C., Rochet M. 1970; Terminal cerebral localization of hepatic alveolar and pulmonary echinococcosis. Apropos of a case. Arch Fr Mal App Dig 59:263–264 (in French
    [Google Scholar]
  5. Brehm K., Jensen K., Frosch M. 2000; mRNA trans-splicing in the human parasitic cestode Echinococcus multilocularis . J Biol Chem 275:38311–38318 [CrossRef]
     [Google Scholar]
  6. Bresson-Hadni S., Vuitton D. A., Bartholomot B., Heyd B., Godart D., Meyer J. P., Hrusovsky S., Becker M. C., Mantion G. other authors 2000; A twenty-year history of alveolar echinococcosis: analysis of a series of 117 patients from eastern France. Eur J Gastroenterol Hepatol 12:327–336 [CrossRef]
     [Google Scholar]
  7. Frosch P. M., Frosch M., Pfister T., Schaad V., Bitter-Suermann D. 1991; Cloning and characterisation of an immunodominant major surface antigen of Echinococcus multilocularis . Mol Biochem Parasitol 48:121–130 [CrossRef]
     [Google Scholar]
  8. Georges S., Villard O., Filisetti D., Mathis A., Marcellin L., Hansmann Y., Candolfi E. 2004; Usefulness of PCR analysis for diagnosis of alveolar echinococcosis with unusual localizations: two case studies. J Clin Microbiol 42:5954–5956 [CrossRef]
     [Google Scholar]
  9. Kern P., Bardonnet K., Renner E., Auer H., Pawlowski Z., Ammann R. W., Vuitton D. A., Kern P. the European Echinococcosis Registry 2003; European echinococcosis registry: human alveolar echinococcosis, Europe, 1982–2000. Emerg Infect Dis 9:343–349 [CrossRef]
     [Google Scholar]
  10. Kern P., Wen H., Sato N., Vuitton D. A., Gruener B., Shao Y., Delabrousse E., Kratzer W., Bresson-Hadni S. 2006; WHO classification of alveolar echinococcosis: principles and application. Parasitol Int 55:Suppl.S283–S287 [CrossRef]
     [Google Scholar]
  11. Qiu M. D., Hun Z. S., Liu S. C., Wen L. C., Wang S. H., Bao L. X. 1986; Intracranial alveolar echinococcosis in China: discussion of surgical treatment. Acta Neurochir (Wien) 82:123–127 [CrossRef]
     [Google Scholar]
  12. Reuter S., Schirrmeister H., Kratzer W., Dreweck C., Reske S. N., Kern P. 1999; Pericystic metabolic activity in alveolar echinococcosis: assessment and follow-up by positron emission tomography. Clin Infect Dis 29:1157–1163 [CrossRef]
     [Google Scholar]
  13. Reuter S., Buck A., Manfras B., Kratzer W., Seitz H. M., Darge K., Reske S. N., Kern P. 2004; Structured treatment interruption in patients with alveolar echinococcosis. Hepatology 39:509–517 [CrossRef]
     [Google Scholar]
  14. Scheuring U. J., Seitz H. M., Wellmann A., Hartlapp J. H., Tappe D., Brehm K., Spengler U., Sauerbruch T., Rockstroh J. K. 2003; Long-term benzimidazole treatment of alveolar echinococcosis with hematogenic subcutaneous and bone dissemination. Med Microbiol Immunol 192:193–195 [CrossRef]
     [Google Scholar]
  15. Schmid M., Pendl G., Samonigg H., Ranner G., Eustacchio S., Reisinger E. C. 1998; Gamma knife radiosurgery and albendazole for cerebral alveolar hydatid disease. Clin Infect Dis 26:1379–1382 [CrossRef]
     [Google Scholar]
  16. Tiaoying L., Jiamin Q., Wen Y., Craig P. S., Xingwang C., Ning X., Ito A., Giraudoux P., Wulamu M. other authors 2005; Echinococcosis in Tibetan populations, western Sichuan Province, China. Emerg Infect Dis 11:1866–1873 [CrossRef]
     [Google Scholar]
  17. Xiao N., Qiu J., Nakao M., Li T., Yang W., Chen X., Schantz P. M., Craig P. S., Ito A. 2006; Echinococcus shiquicus , a new species from the Qinghai–Tibet plateau region of China: discovery and epidemiological implications. Parasitol Int 55:Suppl.S233–S236 [CrossRef]
     [Google Scholar]
  18. Yang Y. R., Vuitton D. A., Jones M. K., Craig P. S., McManus D. P. 2005; Brain metastasis of alveolar echinococcosis in a hyperendemic focus of Echinococcus multilocularis infection. Trans R Soc Trop Med Hyg 99:937–941 [CrossRef]
     [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/jmm.0.2008/002816-0
Loading
Brain and lung metastasis of alveolar echinococcosis in a refugee from a hyperendemic area
J. Med. Microbiol. 57, 1420 (2008); https://doi.org/10.1099/jmm.0.2008/002816-0
/content/journal/jmm/10.1099/jmm.0.2008/002816-0
/content/journal/jmm/10.1099/jmm.0.2008/002816-0
Loading

Data & Media loading...

Most cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error