RT Journal Article SR Electronic(1) A1 Takahashi, Hideyuki A1 Kuroki, Toshiro A1 Watanabe, Yuko A1 Tanaka, Hiroshi A1 Inouye, Hiroo A1 Yamai, Shiro A1 Watanabe, HaruoYR 2004 T1 Characterization of Neisseria meningitidis isolates collected from 1974 to 2003 in Japan by multilocus sequence typing JF Journal of Medical Microbiology, VO 53 IS 7 SP 657 OP 662 DO https://doi.org/10.1099/jmm.0.45541-0 PB Microbiology Society, SN 1473-5644, AB Analysis of 182 Neisseria meningitidis strains isolated over the past 30 years in Japan by serogroup typing and multilocus sequence typing (MLST) was performed. The serogroups of the 182 Japanese isolates were B (103 isolates), Y (39), W135 (1) and non-groupable (39). By MLST analysis, 65 different sequence types (ST) were identified, 42 of which were not found in the MLST database as of January 2004 and seemed to be unique to Japan. Statistical analysis of the MLST results revealed that, although the Japanese isolates seemed to be genetically divergent, they were classified into six major clonal complexes and other minor complexes. Among these isolates, well-documented ST complexes found worldwide were present, such as ST-23 complex (49 isolates), ST-44 complex (41 isolates) and ST-32 complex (8 isolates). On the other hand, a new clonal complex designated ST-2046 complex (28 isolates), which has not been identified in other countries, was also found, suggesting that this clone was indigenous to Japan. Taken together, it was speculated that meningococcal isolates in Japan comprised heterogeneous clones, which were derived both from clones identified in other countries and clones unique to Japan., UL https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.45541-0