%0 Journal Article %A Erridge, Clett %A Pridmore, Alison %A Eley, Adrian %A Stewart, John %A Poxton, Ian R. %T Lipopolysaccharides of Bacteroides fragilis, Chlamydia trachomatis and Pseudomonas aeruginosa signal via Toll-like receptor 2 %D 2004 %J Journal of Medical Microbiology, %V 53 %N 8 %P 735-740 %@ 1473-5644 %R https://doi.org/10.1099/jmm.0.45598-0 %I Microbiology Society, %X Recognition of bacterial lipopolysaccharide (LPS) is critical in the host defence against Gram-negative infection. While enterobacterial LPS signals via Toll-like receptor 4 (TLR4), it has recently been reported that the LPS of Leptospira interrogans, Legionella pneumophila, Rhizobium species Sin-1 and at least one strain of Porphyromonas gingivalis are capable of signalling via TLR2. Using a TLR transfection assay and measurement of an NF-κB-sensitive promoter region, the results show that the LPS of Bacteroides fragilis NCTC-9343, Chlamydia trachomatis LGV-1 and Pseudomonas aeruginosa PAC-611 also signal via TLR2 and it is pointed out that all TLR2-signalling LPS discovered to date demonstrate relatively weak endotoxicity in some models and structural features distinct from those LPS shown to signal via TLR4. %U https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.45598-0