1887

Abstract

A patient with acute promyelocytic leukaemia developed invasive aspergillosis post chemotherapy during a pancytopenic episode, clinically involving the lungs and the gastrointestinal tract. Dichotomously branched septate fungal hyphae were demonstrated microscopically in stools and sputa. Cultures of the samples yielded , which were identical by RFLP and random amplification of polymorphic DNA analyses and antifungal MICs, proving disseminated disease. To the best of the author's knowledge, this is the first time that boluses of fungal hyphae have been demonstrated microscopically in the stools of a patient with gastrointestinal aspergillosis.

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2006-07-01
2024-05-09
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References

  1. Anderson M. J., Gull K., Denning D. W. 1996; Molecular typing by random amplification of polymorphic DNA and M13 Southern hybridization of related paired isolates of Aspergillus fumigatus . J Clin Microbiol 34:87–93
    [Google Scholar]
  2. Ascioglu S., Rex J. H., de Pauw B., Bennett J. E. & 16 other authors; 2002; Invasive Fungal Infections Cooperative Group of the European Organization for Research and Treatment of Cancer; Mycoses Study Group of the National Institute of Allergy and Infectious Diseases. Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hemopoeitic stem cell transplants: an international consensus. Clin Infect Dis 34:7–14 [CrossRef]
    [Google Scholar]
  3. Austwick P. K. C. 1965; Pathogenicity. In The Genus Aspergillus pp  82–126 Edited by Raper K. B., Fennell D. I. Baltimore: Williams & Wilkins;
    [Google Scholar]
  4. Buchheidt D., Skladny H., Baust C., Hehlmann R. 2000; Systemic infections with Candida sp. and Aspergillus sp. in immunocompromised patients with hematological malignancies: current serological and molecular diagnostic methods. Chemotherapy 46:219–228 [CrossRef]
    [Google Scholar]
  5. Denning D. W., Stevens D. A. 1990; Antifungal and surgical treatment of invasive aspergillosis. Review of 2,121 published cases. Rev Infect Dis 12:1147–1201 [CrossRef]
    [Google Scholar]
  6. Denning D. W., Kibbler C. C., Barnes R. A. 2003; British Society for Medical Mycology proposed standards of care for patients with invasive fungal infections. Lancet Infect Dis 3:230–240 [CrossRef]
    [Google Scholar]
  7. Hori A., Kami M., Kishi Y., Mashid U., Matsumura T., Kashima T. 2002; Clinical significance of extra-pulmonary involvement of invasive aspergillosis: a retrospective autopsy-based study of 107 patients. J Hosp Infect 50:175–182 [CrossRef]
    [Google Scholar]
  8. Lass-Florl C., Kofler G., Kropshofer G., Hermans J., Kreczy A., Dierich M. P., Niederwieser D. 1997; In vitro testing of susceptibility to amphotericin B is a reliable predictor of clinical outcome in invasive aspergillosis. J Antimicrob Chemother 40:401–414 [CrossRef]
    [Google Scholar]
  9. Lee S. B., Taylor J. W. 1990; Isolation of DNA from fungal mycelia and single spores. In PCR Protocols: a Guide to Methods and Applications pp  282–287 Edited by Innis M. A., Gelfand D. H., Sninsky J. J., White T. J. San Diego: Academic Press;
    [Google Scholar]
  10. Lin D., Lehmann P. F., Hamory B. H., Padhye A. A., Durry E., Pinner R. W., Lasker B. A. 1995; Comparison of three typing methods for clinical and environmental isolates of Aspergillus fumigatus . J Clin Microbiol 33:1596–1601
    [Google Scholar]
  11. National Committee for Clinical Laboratory Standards 2002 Reference Method for Broth Dilution Antifungal Susceptibility Testing of Filamentous Fungi . Approved standard M38-A Wayne, PA: National Committee for Clinical Laboratory Standards;
    [Google Scholar]
  12. Paterson P. J., Seaton S., Prentice H. G., Kibbler C. C. 2003; Treatment failure in invasive aspergillosis: susceptibility of deep tissue isolates following treatment with amphotericin B. J Antimicrob Chemother 52:873–876 [CrossRef]
    [Google Scholar]
  13. Prescott R. J., Harris M., Banerjee S. S. 1992; Fungal infections of the small and large intestine. J Clin Pathol 45:806–811 [CrossRef]
    [Google Scholar]
  14. Richter S., Cormican M. G., Pfaller M. A., Lee C. K., Gingrich R., Rinaldi M. G., Sutton D. A. 1999; Fatal disseminated Trichoderma longibrachiatum infection in an adult bone marrow transplant patient: species identification and review of the literature. J Clin Microbiol 37:1154–1160
    [Google Scholar]
  15. Schell W. A., Perfect J. R. 1996; Fatal, disseminated Acremonium strictum infection in a neutropenic host. J Clin Microbiol 34:1333–1336
    [Google Scholar]
  16. Soll D. R. 2000; The ins and outs of DNA fingerprinting the infectious fungi. Clin Microbiol Rev 13:332–370 [CrossRef]
    [Google Scholar]
  17. Srivastava V. M., Krishnaswami H., Srivastava A., Dennison D., Chandy M. 1996; Infections in haematological malignancies: an autopsy study of 72 cases. Trans R Soc Trop Med Hyg 90:406–408 [CrossRef]
    [Google Scholar]
  18. Stevens D. A., Kan V. L., Judson M. A. & 7 other authors; 2000; Practice guidelines for diseases caused by Aspergillus . Clin Infect Dis 30:696–709 [CrossRef]
    [Google Scholar]
  19. Working Party of British Society for Antimicrobial Chemotherapy; 1993; Chemoprophylaxis for candidiosis and aspergillosis in neutropenia and transplantation – review and recommendations. J Antimicrob Chemother 32:5–21 [CrossRef]
    [Google Scholar]
  20. Wright J. A., Bradfield S. M., Park J. R., Hawkins D. S. 2003; Prolonged survival after invasive aspergillosis: a single-institution review of 11 cases. J Pediatr Hematol Oncol 25:286–291 [CrossRef]
    [Google Scholar]
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