1887

Abstract

Catechin, a constituent of tea, possesses various bioactivities. In particular, the most abundant catechin in tea is epigallocatechin gallate (EGCg), which has an anti-inflammatory effect. In the present study, the usability of EGCg for osteomyelitis treatment was examined. Osteomyelitis is a difficult disease to cure, partly due to bone lysis caused by infected osteoblasts. Since bone lysis is promoted by proinflammatory cytokines and the receptor activator of NF-B ligand (RANKL), osteoblasts were infected with and the effect of EGCg on the production of cytokines was examined. It was found that the production of interleukin 6 and RANKL was suppressed in the osteoblasts treated with EGCg, which indicated an inflammation suppression effect of EGCg in osteomyelitis treatment.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/jmm.0.47029-0
2007-08-01
2024-03-29
Loading full text...

Full text loading...

/deliver/fulltext/jmm/56/8/1042.html?itemId=/content/journal/jmm/10.1099/jmm.0.47029-0&mimeType=html&fmt=ahah

References

  1. Ahn H. Y., Hadizadeh K. R., Seul C., Yun Y. P., Vetter H., Sachinidis A. 1999; Epigallocathechin-3 gallate selectively inhibits the PDGF-BB-induced intracellular signaling transduction pathway in vascular smooth muscle cells and inhibits transformation of sis -transfected NIH 3T3 fibroblasts and human glioblastoma cells (A172. Mol Biol Cell 10:1093–1104 [CrossRef]
    [Google Scholar]
  2. Azuma Y., Kaji K., Katogi R., Takeshita S., Kudo A. 2000; Tumor necrosis factor- α induces differentiation of and bone resorption by osteoclasts. J Biol Chem 275:4858–4864 [CrossRef]
    [Google Scholar]
  3. Boden M. K., Flock J. I. 1994; Cloning and characterization of a gene for a 19 kDa fibrinogen-binding protein from Staphylococcus aureus . Mol Microbiol 12:599–606 [CrossRef]
    [Google Scholar]
  4. Bost K. L., Ramp W. K., Nicholson N. C., Bento J. L., Marriott I., Hudson M. C. 1999; Staphylococcus aureus infection of mouse or human osteoblasts induces high levels of IL-6 and IL-12 production. J Infect Dis 180:1912–1920 [CrossRef]
    [Google Scholar]
  5. Brown M. D. 1999; Green tea ( Camellia sinensis ) extract and its possible role in the prevention of cancer. Altern Med Rev 4:360–370
    [Google Scholar]
  6. Deutschmann A., Mache C. J., Bodo K., Zebedin D., Ring E. 2005; Successful treatment of chronic recurrent multifocal osteomyelitis with tumor necrosis factor- α blockage. Pediatrics 116:1231–1233 [CrossRef]
    [Google Scholar]
  7. Ellington J. K., Reilly S. S., Ramp W. K., Smeltzer M. S., Kellam J. F., Hudson M. C. 1999; Mechanisms of Staphylococcus aureus invasion of cultured osteoblasts. Microb Pathog 26:317–323 [CrossRef]
    [Google Scholar]
  8. Ellington J. K., Harris M., Webb L., Smith B., Smith T., Tan K., Hudson M. C. 2003; Intracellular Staphylococcus aureus : a mechanism for the indolence of osteomyelitis. J Bone Joint Surg Br 85:918–921
    [Google Scholar]
  9. Hisano M., Yamaguchi K., Inoue Y., Iijima M., Adachi M., Shimamura T. 2003; Inhibitory effect of catechin against the superantigen staphylococcal enterotoxin B (SEB. Arch Dermatol Res 295:183–189 [CrossRef]
    [Google Scholar]
  10. Hu Z. Q., Zhao W. H., Asano N., Yoda Y., Hara Y., Shimamura T. 2002; Epigallocatechin gallate synergistically enhances the activity of carbapenems against methicillin-resistant Staphylococcus aureus . Antimicrob Agents Chemother 46:558–560 [CrossRef]
    [Google Scholar]
  11. Jimi E., Nakamura I., Duong L. T., Ikebe T., Takahashi N., Rodan G. A., Suda T. 1999; Interleukin 1 induces multinucleation and bone-resorbing activity of osteoclasts in the absence of osteoblasts/stromal cells. Exp Cell Res 247:84–93 [CrossRef]
    [Google Scholar]
  12. Kikuchi T., Matsuguchi T., Tsuboi N., Mitani A., Tanaka S., Matsuoka M., Yamamoto G., Hishikawa T., Noguchi T., Yoshikai Y. 2001; Gene expression of osteoclast differentiation factor is induced by lipopolysaccharide in mouse osteoblasts via Toll-like receptors. J Immunol 166:3574–3579 [CrossRef]
    [Google Scholar]
  13. Kobayashi K., Takahashi N., Jimi E., Udagawa N., Takami M., Kotake S., Nakagawa N., Kinosaki M., Yamaguchi K. other authors 2000; Tumor necrosis factor α stimulates osteoclast differentiation by a mechanism independent of the ODF/RANKL-RANK interaction. J Exp Med 191:275–286 [CrossRef]
    [Google Scholar]
  14. Kondo H., Guo J., Bringhurst F. R. 2002; Cyclic adenosine monophosphate/protein kinase A mediates parathyroid hormone/parathyroid hormone-related protein receptor regulation of osteoclastogenesis and expression of RANKL and osteoprotegerin mRNAs by marrow stromal cells. J Bone Miner Res 17:1667–1679 [CrossRef]
    [Google Scholar]
  15. Kono K., Tatara I., Takeda S., Arakawa K., Hara Y. 1994; Antibacterial activity of epigallocatechin gallate against methicillin-resistant Staphylococcus aureus . Kansenshogaku Zasshi 68:1518–1522 [CrossRef]
    [Google Scholar]
  16. Lew D. P., Waldvogel F. A. 1999; Use of quinolones in osteomyelitis and infected orthopaedic prosthesis. Drugs 58 (Suppl. 2):85–91
    [Google Scholar]
  17. Lin Y.-L., Lin J.-K. 1997; (−)-Epigallocatechin-3-gallate blocks the induction of nitric oxide synthase by down-regulating lipopolysaccharide-induced activity of transcription factor nuclear factor- κ B. Mol Pharmacol 52:465–472
    [Google Scholar]
  18. Maeda-Yamamoto M., Inagaki N., Kitaura J., Chikumoto T., Kawahara H., Kawakami Y., Sano M., Miyase T., Tachibana H. other authors 2004; O -methylated catechins from tea leaves inhibit multiple protein kinases in mast cells. J Immunol 172:4486–4492 [CrossRef]
    [Google Scholar]
  19. McDevitt D., Francois P., Vaudaux P., Foster T. J. 1994; Molecular characterization of the clumping factor (fibrinogen receptor) of Staphylococcus aureus . Mol Microbiol 11:237–248 [CrossRef]
    [Google Scholar]
  20. Morris S. K., Brophy J., Richardson S. E., Summerbell R., Parkin P C., Jamieson F., Limerick B., Wiebe L., Ford-Jones E. L. 2006; Blastomycosis in Ontario, 1994–2003. Emerg Infect Dis 12:274–279 [CrossRef]
    [Google Scholar]
  21. Nair S., Song Y., Meghji S., Reddi K., Harris M., Ross A., Poole S., Wilson M., Henderson B. 1995; Surface-associated proteins from Staphylococcus aureus demonstrate potent bone resorbing activity. J Bone Miner Res 10:726–734
    [Google Scholar]
  22. O'Brien C. A., Gubrij I., Lin S.-C., Saylors R. L., Manolagas S. C. 1999; STAT3 activation in stromal/osteoblastic cells is required for induction of the receptor activator of NF- κ B ligand and stimulation of osteoclastogenesis by gp130-utilizing cytokines or interleukin-1 but not 1,25-dihydroxyvitamin D3 or parathyroid hormone. J Biol Chem 274:19301–19308 [CrossRef]
    [Google Scholar]
  23. Okahashi N., Sakurai A., Nakagawa I., Fujiwara T., Kawabata S., Amano A., Hamada S. 2003; Infection by Streptococcus pyogenes induces the receptor activator of NF- κ B ligand expression in mouse osteoblastic cells. Infect Immun 71:948–955 [CrossRef]
    [Google Scholar]
  24. Philpott D. J., Girardin S. E. 2004; The role of Toll-like receptors and Nod proteins in bacterial infection. Mol Immunol 41:1099–1108 [CrossRef]
    [Google Scholar]
  25. Reilly S. S., Hudson M. C., Kellam J. F., Ramp W. K. 2000; In vivo internalization of Staphylococcus aureus by embryonic chick osteoblasts. Bone 26:63–70 [CrossRef]
    [Google Scholar]
  26. Sax H., Lew D. 1999; Osteomyelitis. Curr Infect Dis Rep 1:261–266 [CrossRef]
    [Google Scholar]
  27. Strobel P., Allard C., Perez-Acle T., Calderon R., Aldunate R., Leighton F. 2005; Myricetin, quercetin and catechin-gallate inhibit glucose uptake in isolated rat adipocytes. Biochem J 386:471–478 [CrossRef]
    [Google Scholar]
  28. Suda T., Takahashi N., Udagawa N., Jimi E., Gillespie M. T., Martin T. J. 1999; Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families. Endocr Rev 20:345–357 [CrossRef]
    [Google Scholar]
  29. Takahashi O., Cai Z., Toda M., Hara Y., Shimamura T. 1995; Appearance of antibacterial activity of oxacillin against methicillin resistant Staphylococcus aureus (MRSA) in the presence of catechin. Kansenshogaku Zasshi 69:1126–1134 [CrossRef]
    [Google Scholar]
  30. Takasu H., Sugita A., Uchiyama Y., Katagiri N., Okazaki M., Ogata E., Ikeda K. 2006; c-Fos protein as a target of anti-osteoclastogenic action of vitamin D, and synthesis of new analogs. J Clin Invest 116:528–535 [CrossRef]
    [Google Scholar]
  31. Toda M., Okubo S., Ikigai H., Shimamura T. 1990; Antibacterial and anti-hemolysin activities of tea catechins and their structural relatives. Nippon Saikingaku Zasshi 45:561–566 [CrossRef]
    [Google Scholar]
  32. Umezawa A., Maruyama T., Segawa K., Shadduck R. K., Waheed A., Hata J. 1992; Multipotent marrow stromal cell line is able to induce hematopoiesis in vivo . J Cell Physiol 151:197–205 [CrossRef]
    [Google Scholar]
  33. Wheeler D. S., Catravas J. D., Odoms K., Denenberg A., Malhotra V., Wong H. R. 2004; Epigallocatechin-3-gallate, a green tea-derived polyphenol, inhibits IL-1 β -dependent proinflammatory signal transduction in cultured respiratory epithelial cells. J Nutr 134:1039–1044
    [Google Scholar]
  34. Wright K. M., Friedland J. S. 2004; Regulation of chemokine gene expression and secretion in Staphylococcus aureus -infected osteoblasts. Microbes Infect 6:844–852 [CrossRef]
    [Google Scholar]
  35. Yang F., Oz H. S., Barve S., de Villiers W. J., McClain C. J., Varilek G. W. 2001; The green tea polyphenol (−)-epigallocatechin-3-gallate blocks nuclear factor- κ B activation by inhibiting I κ B kinase activity in the intestinal epithelial cell line IEC-6. Mol Pharmacol 60:528–533
    [Google Scholar]
  36. Yasuda H., Shima N., Nakagawa N., Yamaguchi K., Kinosaki M., Mochizuki S., Tomoyasu A., Yano K., Goto M. other authors 1998; Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. Proc Natl Acad Sci U S A 95:3597–3602 [CrossRef]
    [Google Scholar]
  37. Yoda Y., Hu Z. Q., Zhao W. H., Shimamura T. 2004; Different susceptibilities of Staphylococcus and Gram-negative rods to epigallocatechin gallate. J Infect Chemother 10:55–58 [CrossRef]
    [Google Scholar]
  38. Yoshii T., Magara S., Miyai D., Nishimura H., Kuroki E. 2002; Local levels of interleukin-1 β , ‐4, ‐6 and tumor necrosis factor α in an experimental model of murine osteomyelitis due to Staphylococcus aureus . Cytokine 19:59–65 [CrossRef]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/jmm.0.47029-0
Loading
/content/journal/jmm/10.1099/jmm.0.47029-0
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error