Artemisinin triggers induction of cell-cycle arrest and apoptosis in Leishmania donovani promastigotes
Sen, Rupashree and Bandyopadhyay, Samiran and Dutta, Avijit and Mandal, Goutam and Ganguly, Sudipto and Saha, Piu and Chatterjee, Mitali,, 56, 1213-1218 (2007),
doi = https://doi.org/10.1099/jmm.0.47364-0,
publicationName = Microbiology Society,
issn = 0022-2615,
abstract= A major impediment to effective anti-leishmanial chemotherapy is the emergence of drug resistance, especially to sodium antimony gluconate, the first-line treatment for leishmaniasis. Artemisinin, a sesquiterpene lactone isolated from Artemisia annua, is an established anti-malarial compound that showed anti-leishmanial activity in both promastigotes and amastigotes, with IC50 values of 160 and 22 μM, respectively, and, importantly, was accompanied by a high safety index (>22-fold). The leishmanicidal activity of artemisinin was mediated via apoptosis as evidenced by externalization of phosphatidylserine, loss of mitochondrial membrane potential, in situ labelling of DNA fragments by terminal deoxyribonucleotidyltransferase-mediated dUTP nick end labelling (TUNEL) and cell-cycle arrest at the sub-G0/G1 phase. Taken together, these data indicate that artemisinin has promising anti-leishmanial activity that is mediated by programmed cell death and, accordingly, merits consideration and further investigation as a therapeutic option for the treatment of leishmaniasis.,
language=,
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