Processing of Clostridium difficile toxins Giesemann, Torsten and Egerer, Martina and Jank, Thomas and Aktories, Klaus,, 57, 690-696 (2008), doi = https://doi.org/10.1099/jmm.0.47742-0, publicationName = Microbiology Society, issn = 0022-2615, abstract= The pathogenicity of Clostridium difficile depends on the large clostridial glucosylating toxins A and B (TcdA and TcdB). The proteins accomplish their own uptake by a modular structure comprising a catalytic and a binding/translocation domain. Based on a proteolytic processing step solely the catalytic domain reaches the cytosol. Within the cells, the glucosyltransferases inactivate small GTPases by mono-O-glucosylation. Here, a short overview is given regarding latest insights into the intramolecular processing, which is mediated by an intrinsic protease activity., language=, type=