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Volume 64, Issue 3

High prevalence of sequence type 131 among antimicrobial-resistant isolates from geriatric patients Free

Abstract

Previous work on the subclones within ST131 predominantly involved isolates from Western countries. This study assessed the prevalence and antimicrobial resistance attributed to this clonal group. A total of 340 consecutive, non-duplicated urinary isolates originating from four clinical laboratories in Hong Kong in 2013 were tested. ST131 prevalence among the total isolates was 18.5 % (63/340) and was higher among inpatient isolates (23.0 %) than outpatient isolates (11.8 %, <0.001), and higher among isolates from patients aged ≥65 years than from patients aged 18–50 years and 51–64 years (25.4 vs 3.4 and 4.0 %, respectively, <0.001). Of the 63 ST131 isolates, 43 (68.3 %) isolates belonged to the 30 subclone, whereas the remaining isolates belonged to 41 ( = 17), 54 ( = 2) and 22 ( = 1). All 30 isolates were ciprofloxacin-resistant, of which 18.6 % (8/43) belonged to the 30-Rx subclone. Twenty-six (41.3 %) ST131 isolates were ESBL-producers, of which 19 had (12 non-30-Rx, two 30-Rx and five H41), six had (five non-30-Rx and one 30-Rx) and one was -negative (30). In conclusion, ST131 accounts for a large share of the antimicrobial-resistant isolates from geriatric patients. Unlike previous reports, ESBL-producing ST131 strains mainly belonged to non-30-Rx rather than the 30-Rx subclone, with as the dominant enzyme type.

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© 2015 The Authors
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2015-03-01
2024-04-19
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High prevalence of Escherichia coli sequence type 131 among antimicrobial-resistant E. coli isolates from geriatric patients
J. Med. Microbiol. 64, 243 (2015); https://doi.org/10.1099/jmm.0.000012
/content/journal/jmm/10.1099/jmm.0.000012
/content/journal/jmm/10.1099/jmm.0.000012
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