1887

Abstract

We report a case of fulminant endocarditis on a prosthetic homograft aortic valve caused by , which was successfully managed by surgical valve replacement and antibiotic treatment. , a strictly aerobic, small, Gram-negative coccobacillus, has been implicated as an infrequent cause of a pertussis-like syndrome and other respiratory illnesses. However, is also a rare cause of septicaemia and infective endocarditis, mostly in immunocompromised patients. To our knowledge, this is the first report of endocarditis on a prosthetic aortic valve. Routine laboratory testing initially misidentified the strain as sp. Correct identification was achieved by 16S rRNA gene and outer-membrane protein A () gene sequencing. Interestingly, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry also produced an accurate species-level identification. Subsequent susceptibility testing and review of the literature revealed ceftazidime, cefepime, carbapenems, aminoglycosides, fluoroquinolones, piperacillin/tazobactam, tigecycline and colistin as possible candidates to treat infections caused by .

Loading

Article metrics loading...

/content/journal/jmm/10.1099/jmm.0.038695-0
2012-06-01
2024-03-29
Loading full text...

Full text loading...

/deliver/fulltext/jmm/61/6/874.html?itemId=/content/journal/jmm/10.1099/jmm.0.038695-0&mimeType=html&fmt=ahah

References

  1. Baker G. C., Smith J. J., Cowan D. A. 2003; Review and re-analysis of domain-specific 16S primers. J Microbiol Methods 55:541–555 [View Article][PubMed]
    [Google Scholar]
  2. Bosshard P. P., Zbinden R., Abels S., Böddinghaus B., Altwegg M., Böttger E. C. 2006; 16S rRNA gene sequencing versus the API 20 NE system and the VITEK 2 ID-GNB card for identification of nonfermenting Gram-negative bacteria in the clinical laboratory. J Clin Microbiol 44:1359–1366 [View Article][PubMed]
    [Google Scholar]
  3. Fry N. K., Duncan J., Edwards M. T., Tilley R. E., Chitnavis D., Harman R., Hammerton H., Dainton L. 2007; A UK clinical isolate of Bordetella hinzii from a patient with myelodysplastic syndrome. J Med Microbiol 56:1700–1703 [View Article][PubMed]
    [Google Scholar]
  4. Jannes G., Vaneechoutte M., Lannoo M., Gillis M., Vancanneyt M., Vandamme P., Verschraegen G., Van Heuverswyn H., Rossau R. 1993; Polyphasic taxonomy leading to the proposal of Moraxella canis sp. nov. for Moraxella catarrhalis-like strains. Int J Syst Bacteriol 43:438–449 [View Article][PubMed]
    [Google Scholar]
  5. Lam M. C., Verity R., Tyrrell G. J., Arent R., Nigrin J., Forgie S. E. 2008; Gram-negative bacteremia and asplenia in a well 15-year-old girl. Can J Infect Dis Med Microbiol 19:391–392[PubMed]
    [Google Scholar]
  6. Njamkepo E., Delisle F., Hagege I., Gerbaud G., Guiso N. 2000; Bordetella holmesii isolated from a patient with sickle cell anemia: analysis and comparison with other Bordetella holmesii isolates. Clin Microbiol Infect 6:131–136 [View Article][PubMed]
    [Google Scholar]
  7. Panagopoulos M. I., Saint Jean M., Brun D., Guiso N., Bekal S., Ovetchkine P., Tapiero B. 2010; Bordetella holmesii bacteremia in asplenic children: report of four cases initially misidentified as Acinetobacter lwoffii . J Clin Microbiol 48:3762–3764 [View Article][PubMed]
    [Google Scholar]
  8. Russell F. M., Davis J. M., Whipp M. J., Janssen P. H., Ward P. B., Vyas J. R., Starr M., Sawyer S. M., Curtis N. 2001; Severe Bordetella holmesii infection in a previously healthy adolescent confirmed by gene sequence analysis. Clin Infect Dis 33:129–130 [View Article][PubMed]
    [Google Scholar]
  9. Shepard C. W., Daneshvar M. I., Kaiser R. M., Ashford D. A., Lonsway D., Patel J. B., Morey R. E., Jordan J. G., Weyant R. S., Fischer M. 2004; Bordetella holmesii bacteremia: a newly recognized clinical entity among asplenic patients. Clin Infect Dis 38:799–804 [View Article][PubMed]
    [Google Scholar]
  10. Tang Y.-W., Hopkins M. K., Kolbert C. P., Hartley P. A., Severance P. J., Persing D. H. 1998; Bordetella holmesii-like organisms associated with septicemia, endocarditis, and respiratory failure. Clin Infect Dis 26:389–392 [View Article][PubMed]
    [Google Scholar]
  11. Vaneechoutte M., Claeys G., Steyaert S., De Baere T., Peleman R., Verschraegen G. 2000; Isolation of Moraxella canis from an ulcerated metastatic lymph node. J Clin Microbiol 38:3870–3871[PubMed]
    [Google Scholar]
  12. von Wintzingerode F., Schattke A., Siddiqui R. A., Rösick U., Göbel U. B., Gross R. 2001; Bordetella petrii sp. nov., isolated from an anaerobic bioreactor, and emended description of the genus Bordetella . Int J Syst Evol Microbiol 51:1257–1265[PubMed] [CrossRef]
    [Google Scholar]
  13. Weyant R. S., Hollis D. G., Weaver R. E., Amin M. F., Steigerwalt A. G., O’Connor S. P., Whitney A. M., Daneshvar M. I., Moss C. W., Brenner D. J. 1995; Bordetella holmesii sp. nov., a new gram-negative species associated with septicemia. J Clin Microbiol 33:1–7[PubMed]
    [Google Scholar]
  14. Wirsing von König G.-H., Riffelman M., Coenye T. 2011; Bordetella and related genera. In Manual of Clinical Microbiology, 10th edn. pp. 739–750 Edited by Versalovic J., Carroll K. C., Funke G., Jorgensen J. H., Landry M. L., Warnock D. W. Washington, DC: American Society for Microbiology;
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/jmm.0.038695-0
Loading
/content/journal/jmm/10.1099/jmm.0.038695-0
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error