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Volume 54, Issue 2

Bovine antibody-enriched whey to aid in the prevention of a relapse of -associated diarrhoea: preclinical and preliminary clinical data Free

Abstract

In a pilot study, the feasibility of immune whey protein concentrate (40 %; immune WPC-40) to aid the prevention of relapse of diarrhoea was evaluated. Immune WPC-40 was made from milk after immunization of Holstein–Frisian cows with inactivated toxins and killed whole-cell . Immune WPC-40 contained a high concentration of specific sIgA antibodies, and was effective in neutralizing the cytotoxic effect of toxins in cell assays . Immune WPC-40 conferred protection from otherwise lethal -associated caecitis in hamsters. To obtain preliminary data in humans, 16 patients (10 male; median 57 years) with toxin- and culture-confirmed diarrhoea were enrolled in an uncontrolled cohort study. Nine had a history of relapsing diarrhoea. After completion of standard antibiotic treatment, the patients received immune WPC-40 TID for 2 weeks; it was well tolerated and no treatment-related adverse effects were observed. In all but one case, toxins had disappeared from the faeces upon completion of treatment. During a follow-up period of median 333 days (range 35 days to 1 year), none of the patients had suffered another episode of diarrhoea. These preliminary data suggest that immune whey protein concentrate-40 may be of help in the prevention of relapse of diarrhoea.

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2005-02-01
2024-04-18
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Bovine antibody-enriched whey to aid in the prevention of a relapse of Clostridium difficile-associated diarrhoea: preclinical and preliminary clinical data
J. Med. Microbiol. 54, 197 (2005); https://doi.org/10.1099/jmm.0.45773-0
/content/journal/jmm/10.1099/jmm.0.45773-0
/content/journal/jmm/10.1099/jmm.0.45773-0
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