1887

Abstract

SUMMARY

CBA/N mice, which could not produce antibodies against lipopoly-saccharide (LPS) from either or serovar , produced levels of agglutinating antibodies against leptospires similar to those produced by immunologically normal CBA mice. CBA/N mice were thus resistant to acute leptospiral infection and CBA/N immune serum passively protected immunosuppressed mice from infection. The results suggest that antibodies against LPS are not important in protection against experimental leptospiral infection in mice.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/00222615-15-2-259
1982-05-01
2024-04-25
Loading full text...

Full text loading...

/deliver/fulltext/jmm/15/2/medmicro-15-2-259.html?itemId=/content/journal/jmm/10.1099/00222615-15-2-259&mimeType=html&fmt=ahah

References

  1. Adler B., Faine S. 1976; Susceptibility of mice treated with cyclophosphamide to lethal infection with Leptospira interrogans serovar pomona. Infect. Immun 14:703
    [Google Scholar]
  2. Adler B., Faine S. 1977; Host immunological mechanisms in the resistance of mice to leptospiral infections. Infect. Immun. 17:67
    [Google Scholar]
  3. Adler B., Faine S. 1978; Serological and protective antibody responses of rabbits to leptospiral antigens. J. med Microbiol. 11:401
    [Google Scholar]
  4. Amsbaugh D. F., Hansen C. T., Precott B., Stashak P. W., Barthold D. R., Baker P. J. 1972; Genetic control of the antibody response to type III pneumococcal polysaccharide in mice. I. Evidence that an X-linked gene plays a decisive role in determining responsiveness. J. exp. Med. 136:931
    [Google Scholar]
  5. Chang A., Faine S. 1973; Effect of anti-cell and anti-axial filament sera on Leptospira. Aust. J. exp. Biol. med. Sci. 51:847
    [Google Scholar]
  6. Cohen P. L., Scher I., Mosier D. E. 1976; In vitro studies of the genetically determined unresponsiveness to thymus-independent antigens in CBA/N mice. J. Immun. 116:808
    [Google Scholar]
  7. Edwards P. R., Ewing W. H. 1962 Identification of Enterobacteriaceae. , 2nd. Burgess Publishing Company; Minnesota:
    [Google Scholar]
  8. Faine S., Adler B., Palit A. 1974; Chemical, serological and biological properties of a serotype-specific polysaccharide antigen in Leptospira. Aust. J. exp. Biol. med. Sci. 52:311
    [Google Scholar]
  9. Faîne S., Adler B., Ruta G. 1974; A mechanism of immunity to leptospirosis. Aust. J. exp. Biol, med Sci. 52:301
    [Google Scholar]
  10. Gershon R. K., Kondo K. 1976; Deficient production of a thymus-dependent high affinity antibody subset in mice (CBA/N) with an X-linked B-lymphocyte defect. J. Immun. 117:701
    [Google Scholar]
  11. Hunter K. W., Finkelman F. D., Strickland G. T., Sayles P. C., Scher I. 1979; Defective resistance to Plasmodium yoellii in CBA/N mice. J. Immun. 123:133
    [Google Scholar]
  12. Jayawardena A. N., Janeway C. A., Kemp J. D. 1979; Experimental malaria in the CBA/N mouse. J. Immun. 123:2532
    [Google Scholar]
  13. Neoh S. H., Rowley D. 1970; The antigens of Vibrio cholerae involved in the vibriocidal action of antibody and complement. J. infect. Dis. 121:505
    [Google Scholar]
  14. O’Brien A. D., Scher I., Campbell G. H., MacDermott R. P., Formal S. B. 1979; Susceptibility of CBA/N mice to infection with Salmonella typhimurium: influence of the X-linked gene controlling B lymphocyte function. J. Immun. 123:720
    [Google Scholar]
  15. PleSko I. 1975; Immunogenic activity of some leptospiral extracts. Proceedings of national symposium on leptospirosis, Leptospira and other Spirochaeta, Bucharest 1975, Editura MedicaläBucharest
    [Google Scholar]
  16. Scher I., Steinberg A. D., Berning A. K., Paul W. E. 1975; X-linked B-lymphocyte immune defect in CBA/N mice. II. Studies of the mechanisms underlying the immune defect. J. exp. Med. 142:637
    [Google Scholar]
  17. Scher I., Zaldivar N. M., Mosier D. E. 1977 B-lymphocyte subpopulations and endotoxin response in CBA/N mice. In Microbiology 1977 edited by Schlessinger D. ASM Publications; Washington DC:310
    [Google Scholar]
  18. Weidanz W. P., Jackson A. L., Landy M. 1964; Some aspects of the antibody response of rabbits to immunization with Enterobacterial somatic antigens. Proc. Soc. exp. Biol. Med. 116:832
    [Google Scholar]
  19. Westphal O., Luderitz O., Bister F. 1952; Über die Extraktion von Bakterien mit Phenol Wasser. Z. Naturf B. 7:148
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/00222615-15-2-259
Loading
/content/journal/jmm/10.1099/00222615-15-2-259
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error