@article{mbs:/content/journal/jmm/10.1099/00222615-23-3-199, author = "Mitchell, T. J. and Ketley, J. M. and Burdon, D. W. and Candy, D. C. A. and Stephen, J.", title = "The effects of Clostridium difficile crude toxins and purified toxin A on stripped rabbit ileal mucosa in Ussing chambers", journal= "Journal of Medical Microbiology", year = "1987", volume = "23", number = "3", pages = "199-204", doi = "https://doi.org/10.1099/00222615-23-3-199", url = "https://www.microbiologyresearch.org/content/journal/jmm/10.1099/00222615-23-3-199", publisher = "Microbiology Society", issn = "1473-5644", type = "Journal Article", abstract = "Summary Clostridium difficile crude toxins and purified toxin A had similar effects on stripped rabbit ileal mucosa in Ussing chambers. Both toxin preparations caused secretion of sodium and chloride ions by increasing serosa to mucosa (s→m) fluxes. Transmural potential difference and resistance decreased after toxin treatment. Onset of changes in electrical measurements and ion fluxes coincided with onset of histological changes. The response to theophylline was greatly reduced in toxintreated tissue compared with control tissue.", }