RT Journal Article SR Electronic(1) A1 Mitchell, T. J. A1 Ketley, J. M. A1 Burdon, D. W. A1 Candy, D. C. A. A1 Stephen, J.YR 1987 T1 The effects of Clostridium difficile crude toxins and purified toxin A on stripped rabbit ileal mucosa in Ussing chambers JF Journal of Medical Microbiology, VO 23 IS 3 SP 199 OP 204 DO https://doi.org/10.1099/00222615-23-3-199 PB Microbiology Society, SN 1473-5644, AB Summary Clostridium difficile crude toxins and purified toxin A had similar effects on stripped rabbit ileal mucosa in Ussing chambers. Both toxin preparations caused secretion of sodium and chloride ions by increasing serosa to mucosa (s→m) fluxes. Transmural potential difference and resistance decreased after toxin treatment. Onset of changes in electrical measurements and ion fluxes coincided with onset of histological changes. The response to theophylline was greatly reduced in toxintreated tissue compared with control tissue., UL https://www.microbiologyresearch.org/content/journal/jmm/10.1099/00222615-23-3-199