An ascending non-obstructive model for chronic pyelonephritis in BALB/c mice
Gupta, R. and Ganguly, N. K. and Ahuja, Varinder and Joshi, Kusem and Sharma, Saroj,, 43, 33-36 (1995),
doi = https://doi.org/10.1099/00222615-43-1-33,
publicationName = Microbiology Society,
issn = 0022-2615,
abstract= Summary Chronic pyelonephritis was successfully produced in female BALB/c mice with Escherichia coli after introduction of the bacterial inoculum by the ascending route. E. coli strain 31-B, a nalidixic acid-resistant derivative of strain TN675 expressing type-1 pili, and E. coli strain BH-5, a mutant of 31-B, not expressing type-1 pili, were used in the model. Both the strains were able to induce chronic renal inflammation in the experimental animals. Whereas the initial colonisation was greater with strain 31-B, its non-pilate mutant BH-5 caused a significantly greater inflammatory response and also caused renal scarring observable 5 months after the infection.,
language=,
type=