1887

Abstract

Summary

Groups of mice were immunised against with heatkilled (HK) and acetone-killed (AK) vaccines or with their ultrasonic or Mickledisintegrated forms and subsequently challenged by the oral or intraperitoneal routes. All six vaccine preparations conferred statistically significant protection against intraperitoneal challenge as measured by reduced mortality, lowered infection rate and prolonged survival. Of the six vaccines, only the Mickledisintegrated HK vaccine significantly reduced the mortality rate of mice challenged by the oral route.

Filtered bacteria-free extracts of homogenates of infected mouse liver conferred active immunity against a massive intraperitoneal challenge, but similar extracts of normal liver or of spleen from normal or infected animals were without effect.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/00222615-5-2-183
1972-05-01
2024-04-20
Loading full text...

Full text loading...

/deliver/fulltext/jmm/5/2/medmicro-5-2-183.html?itemId=/content/journal/jmm/10.1099/00222615-5-2-183&mimeType=html&fmt=ahah

References

  1. Cronly-Dillon, Sujatha (nee Panikker) 1967 M.Sc. Thesis University of Edinburgh; Studies on infection and immunity in experimental mouse typhoid.
    [Google Scholar]
  2. Hobson D. 1957a; Resistance to reinfection in experimental mouse typhoid. J. Hyg., Camb 55:334
    [Google Scholar]
  3. Hobson D. 1957b; Chronic bacterial carriage in survivors of experimental mouse typhoid. J. Path. Bact 73:399
    [Google Scholar]
  4. Kawakami M., Osawa N., Mitsuhashi S. 1966; Experimental salmonellosis. VII. Comparison of the immunizing effect of live vaccine and materials extracted from Salmonella typhimurium. J. Bact 92:1585
    [Google Scholar]
  5. MacLeod D. R. E. 1954; Immunity to salmonella infection in mice. J. Hyg., Camb 52:9
    [Google Scholar]
  6. Miles A. A., Misra S. S., Irwin J. O. 1938; The estimation of the bactericidal power of the blood. J. Hyg., Camb 38:732
    [Google Scholar]
  7. Olitzki A. L., Godinger D. 1963; Comparative studies on Salmonella typhi grown in vivo and in vitro. III. The immunizing potencies of acetone-killed vaccines prepared from in vivo- and in v/Vro-grown bacteria and the immunizing potency of substances isolated from infected organs. J. Hyg., Camb 61:353
    [Google Scholar]
  8. Raistrick H., Topley W. W. C. 1934; Immunizing fractions isolated from Bact. aertrycke. Br. J. Exp. Path 15:113
    [Google Scholar]
  9. Topley W. W. C., Greenwood M., Wilson Joyce. 1931; A strain of Bact. aertrycke with unusual epidemic characters. J. Path. Bact 34:523
    [Google Scholar]
  10. Weir D. M. 1967; The immunological consequences of cell death. Lancet 2:1071
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/00222615-5-2-183
Loading
/content/journal/jmm/10.1099/00222615-5-2-183
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error