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Volume 64, Issue 4

and carriage in healthy school-age children and adolescents Free

Abstract

and are common commensals of the upper respiratory tract in children and adolescents. Understanding the relationship between these two pathogens, including their potential for mutual interference, is needed to evaluate the epidemiology of the diseases they cause, the factors that condition acquisition and carriage, and the impact of related preventative measures. We obtained oropharyngeal and nasal swabs from 497 healthy subjects aged 6–17 years. detection and serotyping were performed using a real-time PCR and detection was performed using the RIDAGENE MRSA system. We found that 136 (27.3 %) of the children were carriers of both species, 121 (24.3 %) of the children carried alone and 128 (25.7 %) of the children carried alone. carriage was similar between children who carried (136/257, 52.9 %, 95 % confidence interval [CI]: 46.8–58.9 %) vs those who did not (128/240, 53.3 %, 95 % CI: 47.0 –59.5 %) and was independent of age and vaccination with 7-valent pneumococcal conjugate vaccine (PCV7). Vaccination with PCV7 did not affect carriage [: 84/143 (58.7 %, 95 % CI: 50.5 –66.5 %) vaccinated children vs 171/351 (48.7 %, 95 % CI: 43.5 –53.9 %) unvaccinated children; S. : 67/143 (46.9 %, 95 % CI: 38.9–55.0 %) vaccinated children vs 195/351 (55.6 %, 95 % CI: 50.3 –60.7 %) unvaccinated children]. Pneumococcal serotype also did not appear to affect carriage. These findings suggested that the carriage of did not affect that of in older children and adolescents, regardless of age, PCV7 vaccination and pneumococcal serotype.

  • Received:
  • Accepted:
  • Published Online:
© 2015 The Authors
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2015-04-01
2024-04-16
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References

  1. Bogaert D., van Belkum A., Sluijter M., Luijendijk A., de Groot R., Rümke H. C., Verbrugh H. A., Hermans P. W. 2004; Colonisation by Streptococcus pneumoniae and Staphylococcus aureus in healthy children. Lancet 363:1871–1872 [View Article][PubMed]
     [Google Scholar]
  2. Cohen R., Levy C., Thollot F., de La Rocque F., Koskas M., Bonnet E., Fritzell B., Varon E. 2007; Pneumococcal conjugate vaccine does not influence Staphylococcus aureus carriage in young children with acute otitis media. Clin Infect Dis 45:1583–1587 [View Article][PubMed]
     [Google Scholar]
  3. Dukers-Muijrers N. H. T. M., Stobberingh E., Beisser P., Boesten R. C. H., Jacobs P., Hoebe C. J. P. A. 2013; Nasal carriage of Streptococcus pneumoniae serotypes and Staphylococcus aureus in Streptococcus pneumoniae-vaccinated and non-vaccinated young children. Epidemiol Infect 141:631–638 [View Article][PubMed]
     [Google Scholar]
  4. Esposito S., Marchese A., Tozzi A. E., Rossi G. A., Da Dalt L., Bona G., Pelucchi C., Schito G. C., Principi N.Italian Pneumococcal CAP Group 2012; Bacteremic pneumococcal community-acquired pneumonia in children less than 5 years of age in Italy. Pediatr Infect Dis J 31:705–710 [View Article][PubMed]
     [Google Scholar]
  5. Kluytmans J., van Belkum A., Verbrugh H. 1997; Nasal carriage of Staphylococcus aureus: epidemiology, underlying mechanisms, and associated risks. Clin Microbiol Rev 10:505–520[PubMed]
     [Google Scholar]
  6. Kwambana B. A., Barer M. R., Bottomley C., Adegbola R. A., Antonio M. 2011; Early acquisition and high nasopharyngeal co-colonisation by Streptococcus pneumoniae and three respiratory pathogens amongst Gambian new-borns and infants. BMC Infect Dis 11:175 [View Article][PubMed]
     [Google Scholar]
  7. Le Polain de Waroux O., Flasche S., Prieto-Merino D., Edmunds W. J. 2014; Age-dependent prevalence of nasopharyngeal carriage of streptococcus pneumoniae before conjugate vaccine introduction: a prediction model based on a meta-analysis. PLoS ONE 9:e86136 [View Article][PubMed]
     [Google Scholar]
  8. McNally L. M., Jeena P. M., Gajee K., Sturm A. W., Tomkins A. M., Coovadia H. M., Goldblatt D. 2006; Lack of association between the nasopharyngeal carriage of Streptococcus pneumoniae and Staphylococcus aureus in HIV-1-infected South African children. J Infect Dis 194:385–390 [View Article][PubMed]
     [Google Scholar]
  9. Mertz D., Frei R., Periat N., Zimmerli M., Battegay M., Flückiger U., Widmer A. F. 2009; Exclusive Staphylococcus aureus throat carriage: at-risk populations. Arch Intern Med 169:172–178 [View Article][PubMed]
     [Google Scholar]
  10. Principi N., Terranova L., Zampiero A., Manzoni F., Senatore L., Rios W. P., Esposito S. 2014; Oropharyngeal and nasopharyngeal sampling for the detection of adolescent Streptococcus pneumoniae carriers. J Med Microbiol 63:393–398 [View Article][PubMed]
     [Google Scholar]
  11. Quintero B., Araque M., van der Gaast-de Jongh C., Escalona F., Correa M., Morillo-Puente S., Vielma S., Hermans P. W. M. 2011; Epidemiology of Streptococcus pneumoniae and Staphylococcus aureus colonization in healthy Venezuelan children. Eur J Clin Microbiol Infect Dis 30:7–19 [View Article][PubMed]
     [Google Scholar]
  12. Regev-Yochay G., Dagan R., Raz M., Carmeli Y., Shainberg B., Derazne E., Rahav G., Rubinstein E. 2004; Association between carriage of Streptococcus pneumoniae and Staphylococcus aureus in Children. JAMA 292:716–720 [View Article][PubMed]
     [Google Scholar]
  13. Simell B., Auranen K., Käyhty H., Goldblatt D., Dagan R., O’Brien K. L.Pneumococcal Carriage Group 2012; The fundamental link between pneumococcal carriage and disease. Expert Rev Vaccines 11:841–855 [View Article][PubMed]
     [Google Scholar]
  14. Veenhoven R., Bogaert D., Uiterwaal C., Brouwer C., Kiezebrink H., Bruin J., IJzerman E., Hermans P., de Groot R. et al. 2003; Effect of conjugate pneumococcal vaccine followed by polysaccharide pneumococcal vaccine on recurrent acute otitis media: a randomised study. Lancet 361:2189–2195 [View Article][PubMed]
     [Google Scholar]
  15. Wertheim H. F. L., Melles D. C., Vos M. C., van Leeuwen W., van Belkum A., Verbrugh H. A., Nouwen J. L. 2005; The role of nasal carriage in Staphylococcus aureus infections. Lancet Infect Dis 5:751–762 [View Article][PubMed]
     [Google Scholar]
  16. Xu Q., Almudervar A., Casey J. R., Pichichero M. E. 2012; Nasopharyngeal bacterial interactions in children. Emerg Infect Dis 18:1738–1745 [View Article][PubMed]
     [Google Scholar]
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Streptococcus pneumoniae and Staphylococcus aureus carriage in healthy school-age children and adolescents
J. Med. Microbiol. 64, 427 (2015); https://doi.org/10.1099/jmm.0.000029
/content/journal/jmm/10.1099/jmm.0.000029
/content/journal/jmm/10.1099/jmm.0.000029
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