Accuracy of in vitro susceptibility tests for carbapenemase-producing Gram-negative bacteria
Sun, Jingyong and Xu, Yingchun and Yu, Yunsong and Ni, Yuxing,, 64, 620-622 (2015),
doi = https://doi.org/10.1099/jmm.0.000067,
publicationName = Microbiology Society,
issn = 0022-2615,
abstract= Accurate susceptibility results on antibiotic-resistant bacteria are essential for proper treatment of infections. In this study, 100 metallo-β-lactamase (MBL)-producing strains and 95 isolates with Klebsiella pneumoniae carbapenemase (KPC) were tested for carbapenem susceptibility using two automated platforms, the Phoenix and Vitek-2 systems, and a manual Etest. Phoenix showed higher categorical agreements (97 % for imipenem and 94 % for meropenem) compared with those from Vitek-2 (92 and 74 %) and Etest (89 and 96 %), respectively, when testing MBL strains. Categorical agreement for imipenem tests with KPC-producing strains was 88.4 % with the Phoenix system, 83.2 % with the Vitek 2 system and 90.5 % with the Etest. Categorical agreement was 100 % for all tests with ertapenem. In conclusion, the Phoenix system demonstrated a higher accuracy than Vitek-2 in testing carbapenemase-producing strains, particularly in MBL strains.,
language=,
type=