Challenges facing the drug discovery pipeline for non-tuberculous mycobacteria
Soni, Isha and De Groote, Mary Ann and Dasgupta, Arunava and Chopra, Sidharth,, 65, 1-8 (2016),
doi = https://doi.org/10.1099/jmm.0.000198,
publicationName = Microbiology Society,
issn = 0022-2615,
abstract= Non-tuberculous mycobacteria (NTM) infections are increasingly being reported worldwide. They are a major concern for healthcare professionals for multiple reasons, ranging from the intrinsic resistance of NTM to most conventionally utilized antimicrobials to inharmonious diagnostic criteria utilized for evaluation of NTM-infected patients, leading to high morbidity. In this review, we highlight the paucity of drugs having potent anti-NTM activity amongst the new antimicrobials currently under various stages of development for anti-tubercular activity and issue a call for the establishment of a concerted dedicated drug discovery pipeline targeting NTM.,
language=,
type=