RT Journal Article SR Electronic(1) A1 Nakajima, Akiko A1 Ikeda, Fumiaki A1 Kanayama, Shoji A1 Okamoto, Kazuaki A1 Matsumoto, Tatsumi A1 Ishii, Ritsuko A1 Fujikawa, Akira A1 Takei, Katsuaki A1 Kawashima, MakotoYR 2016 T1 Antimicrobial activities of ozenoxacin against isolates of propionibacteria and staphylococci from Japanese patients with acne vulgaris JF Journal of Medical Microbiology, VO 65 IS 8 SP 745 OP 750 DO https://doi.org/10.1099/jmm.0.000293 PB Microbiology Society, SN 1473-5644, AB Ozenoxacin, a novel non-fluorinated topical quinolone, was assessed for in vitro antimicrobial activity against clinical isolates of propionibacteria and staphylococci according to the broth microdilution method recommended by the Clinical and Laboratory Standards Institute. The isolates used in this study were collected from Japanese patients with acne vulgaris during a period from 2012 to 2013. The MIC90s of ozenoxacin against Propionibacterium acnes (n=266), Propionibacterium granulosum (n=10), Staphylococcus aureus (n=23), Staphylococcus epidermidis (n=229) and other coagulase-negative staphylococci (n=82) were ≤0.06, ≤0.06, ≤0.06, 0.125 and ≤0.06 µg ml−1, respectively. The antimicrobial activity of ozenoxacin against the clinical isolates of propionibacteria and staphylococci was greater than that of five reference antimicrobial agents which have been used for the treatment of acne vulgaris. The MICs of ozenoxacin were correlated with those of nadifloxacin in P. acnes and S. epidermidis isolates. However, the MICs of ozenoxacin were 0.25–0.5 µg ml−1 and 0.5–8 µg ml−1 against nadifloxacin-resistant P. acnes (MIC: ≥8 µg ml−1; n=8) and S. epidermidis (MIC: ≥64 µg ml−1; n=10), respectively. These results indicated the potent antimicrobial activity against P. acnes and S. epidermidis isolates resistant to nadifloxacin. Topical ozenoxacin could represent an alternative therapeutic drug for acne vulgaris based on its potent antimicrobial activity against the isolates of propionibacteria and staphylococci from acne patients., UL https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.000293