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Volume 65, Issue 12

Antimicrobial susceptibility to azithromycin among Typhi and Paratyphi A isolates from India Free

Abstract

Decreased ciprofloxacin susceptibility (DCS) and multidrug resistance in typhoidal isolates in areas of endemicity are significant therapeutic problems. Guidelines for azithromycin disc diffusion and MIC interpretive criteria for serovar Typhi were published recently by the Clinical and Laboratory Standards Institute in 2015. We investigated the antimicrobial susceptibility pattern of azithromycin in 100 isolates of Typhi (=80), Paratyphi A (=18) and B (=2) recovered from bloodstream infections from January 2013 to December 2015. Zone sizes were extrapolated against MIC values, and a scatter plot was constructed. The azithromycin MICs by Etest ranged from 2 to 16 µg ml, while the disc diffusion diameters were from 13 to 22 mm. We observed that the margin of the zone of inhibition around the azithromycin disc may not be very clear and therefore difficult to interpret and that there was wide variation in the zone sizes for the same MIC value in both serovars. DCS was observed in 85 % of Typhi recovered (68/80) and in 15/18 (83.3 %) Paratyphi A isolates. Judicious use of azithromycin is advocated as an alternative oral agent in endemic areas where DCS is common.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): Antimicrobial susceptibility pattern. , Azithromycin , Paratyphi , Salmonella enterica and Typhi
© 2016 The Authors
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2016-12-16
2024-04-20
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Antimicrobial susceptibility to azithromycin among Salmonella enterica Typhi and Paratyphi A isolates from India
J. Med. Microbiol. 65, 1536 (2016); https://doi.org/10.1099/jmm.0.000390
/content/journal/jmm/10.1099/jmm.0.000390
/content/journal/jmm/10.1099/jmm.0.000390
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