1887

Abstract

The objective of the present study was to determine the frequency and age distribution of different (CT) genotypes causing ophthalmia neonatorum (ON) in Hungary. Using CT specific PCR, we tested 76 conjunctival samples from symptomatic infants up to 3 months old in the National Centre for Epidemiology, Budapest between 2008 and 2016. CT tested positive in 30 of 76 conjunctival samples (39.5 %). The sequencing of the positive samples was successful in every case but one, and resulted in 48 % dominance for genotype E (14/29), followed by 24 % for genotype G (7/29), 10 % for J (3/29), 6.9 % for K and F (2/29), and 3.4 % for H (1/29). CT must still be regarded as a common pathogen causing ON in Hungary. Routine screening and treatment of pregnant women can be recommended to prevent these conditions. Chronic ON cases can be reduced by early diagnosis. Further research is needed to explain the dominance of genotypes E and G.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/jmm.0.000523
2017-07-01
2024-03-28
Loading full text...

Full text loading...

/deliver/fulltext/jmm/66/7/915.html?itemId=/content/journal/jmm/10.1099/jmm.0.000523&mimeType=html&fmt=ahah

References

  1. European Centre for Disease Prevention and Control Sexually Transmitted Infections in Europe 2013 Stockholm: ECDC; 2015
    [Google Scholar]
  2. Workowski KA, Bolan GA. Centers for Disease Control and Prevention Sexually transmitted diseases treatment guidelines, 2015. MMWR Recomm Rep 2015; 64:1-137[PubMed]
    [Google Scholar]
  3. Hammerschlag MR. Chlamydial and gonococcal infections in infants and children. Clin Infect Dis 2011; 53:S99–S102 [View Article][PubMed]
    [Google Scholar]
  4. Rosenman MB, Mahon BE, Downs SM, Kleiman MB. Oral erythromycin prophylaxis vs watchful waiting in caring for newborns exposed to Chlamydia trachomatis. Arch Pediatr Adolesc Med 2003; 157:565–571 [View Article][PubMed]
    [Google Scholar]
  5. Numazaki K, Wainberg MA, Mcdonald J. Chlamydia trachomatis infections in infants. Can Med Ass J 1989; 140:615–622
    [Google Scholar]
  6. Moore DL, MacDonald NE. Canadian Paediatric Society, Infectious Diseases and Immunization Committee Preventing ophthalmia neonatorum. Paediatr Child Health 2015; 20:93–96 [View Article]
    [Google Scholar]
  7. Matejcek A, Goldman RD. Treatment and prevention of ophthalmia neonatorum. Can Fam Physician 2013; 59:1187–1190[PubMed]
    [Google Scholar]
  8. Petrovay F, Németh I, Balázs A, Balla E. Chlamydial conjunctivitis: prevalence and serovar distribution of Chlamydia trachomatis in adults. J Med Microbiol 2015; 64:967–970 [View Article][PubMed]
    [Google Scholar]
  9. Salpietro CD, Bisignano G, Fulia F, Marino A, Barberi I. [Chlamydia trachomatis conjunctivitis in the newborn]. Arch Pediatr 1999; 6:317–320 (in French with English abstract) [View Article][PubMed]
    [Google Scholar]
  10. Darville T. Chlamydia trachomatis infections in neonates and young children. Semin Pediatr Infect Dis 2005; 16:235–244 [View Article][PubMed]
    [Google Scholar]
  11. American Academy of Ophthalmology 2008 Preferred Practice Pattern Conjunctivitis San Francisco, CA: American Academy of Ophthalmology; http://one.aao.org/CE/PracticeGuidelines/PPP_Content.aspx?cid=9d9650fb-39a3–439c-9225–5fbb013cf472 accessed 14 December, 2010
    [Google Scholar]
  12. Fermepin MR, Entrocassi AC, Sauka DH, Vaulet ML, Corominas AI. Chlamydia trachomatis serovars in Buenos Aires, Argentina: predominance of serovar E in ophthalmia neonatorum. Sex Transm Dis 2007; 34:1041 [View Article][PubMed]
    [Google Scholar]
  13. Gallo Vaulet L, Entrocassi C, Corominas AI, Rodríguez Fermepin M. Distribution study of Chlamydia trachomatis genotypes in symptomatic patients in Buenos Aires, Argentina: association between genotype E and neonatal conjunctivitis. BMC Res Notes 2010; 3:34–36 [View Article][PubMed]
    [Google Scholar]
  14. Kese D, Potocnik M, Maticic M, Kogoj R. Genotyping of Chlamydia trachomatis directly from urogenital and conjunctiva samples using an ompA gene pyrosequencing-based assay. FEMS Immunol Med Microbiol 2011; 63:210–216 [View Article][PubMed]
    [Google Scholar]
  15. Petrovay F, Balla E, Németh I, Gönczöl E. Genotyping of Chlamydia trachomatis from the endocervical specimens of high-risk women in Hungary. J Med Microbiol 2009; 58:760–764 [View Article][PubMed]
    [Google Scholar]
  16. Donders GG, Moerman P, de Wet GH, Hooft P, Goubau P. The association between Chlamydia cervicitis, chorioamnionitis and neonatal complications. Arch Gynecol Obstet 1991; 249:79–85 [View Article][PubMed]
    [Google Scholar]
  17. Haggerty CL, Panum I, Uldum SA, Bass DC, Olsen J et al. Chlamydia trachomatis infection may increase the risk of preeclampsia. Pregnancy Hypertens 2013; 3:28–33 [View Article][PubMed]
    [Google Scholar]
  18. Blas MM, Canchihuaman FA, Alva IE, Hawes SE. Pregnancy outcomes in women infected with Chlamydia trachomatis: a population-based cohort study in Washington State. Sex Transm Infect 2007; 83:314–318 [View Article][PubMed]
    [Google Scholar]
  19. Silveira MF, Ghanem KG, Erbelding EJ, Burke AE, Johnson HL et al. Chlamydia trachomatis infection during pregnancy and the risk of preterm birth: a case-control study. Int J STD AIDS 2009; 20:465–469 [View Article][PubMed]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/jmm.0.000523
Loading
/content/journal/jmm/10.1099/jmm.0.000523
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error