
oa High levels of macrolide-resistant Mycoplasma genitalium in Queensland, Australia
- Authors: Ella Trembizki1 , Cameron Buckley1 , Cheryl Bletchly2 , Graeme R. Nimmo2 , David M. Whiley1,2
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1 1UQ Centre for Clinical Research, The University of Queensland, Brisbane, Queensland 4029, Australia 2 2Pathology Queensland Central Laboratory, Brisbane, Queensland 4029, Australia
- *Correspondence: David M. Whiley [email protected]
- First Published Online: 12 September 2017, Journal of Medical Microbiology 66: 1451-1453, doi: 10.1099/jmm.0.000584
- Subject: Clinical Microbiology
- Received:
- Accepted:
- Cover date:
- This is an open access article published by the Microbiology Society under the Creative Commons Attribution License




High levels of macrolide-resistant Mycoplasma genitalium in Queensland, Australia, Page 1 of 1
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The macrolide azithromycin is recommended for treatment of Mycoplasma genitalium infection; however, M. genitalium strains possessing macrolide resistance-mediating mutations (MRMMs) are increasingly being reported. Here, we used the SpeeDx ResistancePlus MG kit, which provides simultaneous detection of M. genitalium and MRMMs, to assess MRMM carriage among M. genitalium infections in Queensland, Australia. Performance characteristics of the ResistancePlus MG kit for M. genitalium detection were compared to in-house PCR. Available M. genitalium PCR-positive (n=67) and negative (n=281) samples from the years 2011 to 2017 were tested using the SpeeDx ResistancePlus MG kit. In total, 63.6 % M. genitalium-positive samples were indicated to harbour MRMMs. The ResistancePlus MG method provided sensitivity and specificity of 97 and 99.6 % respectively compared to in-house PCR for M. genitalium detection. Such high levels of macrolide-resistant M. genitalium raise further concerns over future use of azithromycin for treatment of M. genitalium infection.
- Keyword(s): macrolide, Mycoplasma genitalium, antimicrobial resistance
© 2017 The Authors | Published by the Microbiology Society
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