%0 Journal Article %A Yan, Dong %A Chen, Yunbo %A Lv, Tao %A Huang, Yandi %A Yang, Jiezuan %A Li, Yongtao %A Huang, Jianrong %A Li, Lanjuan %T Clostridium difficile colonization and infection in patients with hepatic cirrhosis %D 2017 %J Journal of Medical Microbiology, %V 66 %N 10 %P 1483-1488 %@ 1473-5644 %R https://doi.org/10.1099/jmm.0.000596 %K risk factor %K Infection %K hepatic cirrhosis %K colonization %K Clostridium difficile %I Microbiology Society, %X Objective. The aim of this study was to investigate the toxigenic Clostridium difficile colonization (CDC, colonization with toxigenic C. difficile but without symptoms) and C. difficile infection (CDI, active C. difficile infection resulting in disease symptoms) in hepatic cirrhosis patients, identify the risk factors of CDC, and determine the correlation between CDC and CDI. Methodology. The strains of toxigenic C. difficile were isolated from patients with hepatic cirrhosis within 48 h after admission, followed by multilocus sequence typing (MLST). Patients were divided into toxigenic CDC group and noncolonized (NC) group according to the colonization. Logistic regression analysis was performed to analyse the risk factors for the CDC. Besides, the CDI incidence was compared between the two groups. Results. Colonization of toxigenic C. difficile was identified in 104 cases (19.8 %). Eighteen sequence types (STs) were identified, among which ST-3, ST-54, ST-35 and ST-37 were the predominant types. Child-Pugh class C(relative risk, RR, 3.025; 95 % CI: 1.410–6.488), decrease of prothrombin time activity (PTA) (RR 2.180; 95 % CI: 1.368–3.476), decrease of platelet (RR 2.746; 95 % CI: 0.931–8.103) and concurrent hepatic encephalopathy (RR 1.740; 95 % CI: 1.012–2.990) were identified as the risk factors for the hepatic cirrhosis patients with CDC. The CDI incidence in the CDC group was also significantly higher than that of the NC group (26.0 % vs 1.7 %, P<0.001). Conclusion. An carriage rate of 19.8 % was reported in the hepatic cirrhosis patients with C. difficile colonization. Child's class C, decrease of PTA and platelet, and concurrent hepatic encephalopathy were the risk factors for the hepatic cirrhosis patients with C. difficile colonization. Hepatic cirrhosis patients with C. difficile colonization were more susceptible to CDI. %U https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.000596