1887

Journal of Medical Microbiology logo

Volume 67, Issue 1

Disseminated methicillin-susceptible infection Free

Abstract

When clinicians think about bacteria, what comes to the mind of most is the dreaded methicillin-resistant form. However, clinicians should not forget the methicillin-susceptible type, which is just as virulent.

The authors present the case of a 20-year-old woman who was admitted with septic shock and multi-organ failure and was found to have disseminated methicillin-susceptible (MSSA) infection. The patient had persistent blood cultures positive for MSSA. A transesophageal echocardiogram showed a 1.1 cm vegetation in the mitral valve, and the patient had bilateral pleural effusions that grew MSSA. An MRI of the brain showed multiple areas consistent with infarctions thought to be secondary to septic emboli. The patient underwent a mitral valve replacement and was treated with a prolonged course of parenteral nafcillin.

This case illustrates a severe clinical presentation and management of MSSA infections.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): methicillin-susceptible Staphylococcus aureus infection , multi-organ failure and septic shock
© 2018 The Authors
Loading

Article metrics loading...

/content/journal/jmm/10.1099/jmm.0.000644
2018-01-01
2024-04-25
Loading full text...

Full text loading...

/deliver/fulltext/jmm/67/1/83.html?itemId=/content/journal/jmm/10.1099/jmm.0.000644&mimeType=html&fmt=ahah

References

  1. Lucet JC, Regnier B. Screening and decolonization: does methicillin-susceptible Staphylococcus aureus hold lessons for methicillin-resistant S. aureus?. Clin Infect Dis 2010; 51:585–590 [View Article][PubMed]
     [Google Scholar]
  2. Cosgrove SE, Sakoulas G, Perencevich EN, Schwaber MJ, Karchmer AW et al. Comparison of mortality associated with methicillin-resistant and methicillin-susceptible Staphylococcus aureus bacteremia: a meta-analysis. Clin Infect Dis 2003; 36:53–59 [View Article][PubMed]
     [Google Scholar]
  3. Baddour LM, Wilson WR, Bayer AS, Fowler VG, Tleyjeh IM. et al. Infective endocarditis in adults: diagnosis, antimicrobial therapy, and management of complications: a scientific statement for healthcare professionals from the American Heart Association. Circulation 2015; 132:1435–1486 [View Article][PubMed]
     [Google Scholar]
  4. del Rio A, Cervera C, Moreno A, Moreillon P, Miró JM. Patients at risk of complications of Staphylococcus aureus bloodstream infection. Clin Infect Dis 2009; 48:S246–S253 [View Article][PubMed]
     [Google Scholar]
  5. van Hal SJ, Jensen SO, Vaska VL, Espedido BA, Paterson DL et al. Predictors of mortality in Staphylococcus aureus bacteremia. Clin Microbiol Rev 2012; 25:362–386 [View Article][PubMed]
     [Google Scholar]
  6. Nadji G, Remadi JP, Coviaux F, Mirode AA, Brahim A et al. Prognostic factors in left-sided endocarditis: results from the andalusian multicenter cohort. Heart 2005; 91:932–937
     [Google Scholar]
  7. Shorr AF, Tabak YP, Killian AD, Gupta V, Liu LZ et al. Healthcare-associated bloodstream infection: A distinct entity? Insights from a large U.S. database. Crit Care Med 2006; 34:2588–2595 [View Article][PubMed]
     [Google Scholar]
  8. Khatib R, Saeed S, Sharma M, Riederer K, Fakih MG et al. Impact of initial antibiotic choice and delayed appropriate treatment on the outcome of Staphylococcus aureus bacteremia. Eur J Clin Microbiol Infect Dis 2006; 25:181–185 [View Article][PubMed]
     [Google Scholar]
  9. Corey GR. Staphylococcus aureus bloodstream infections: definitions and treatment. Clin Infect Dis 2009; 48:S254–S259 [View Article][PubMed]
     [Google Scholar]
  10. Lee S, Choe PG, Song KH, Park SW, Kim HB et al. Is cefazolin inferior to nafcillin for treatment of methicillin-susceptible Staphylococcus aureus bacteremia?. Antimicrob Agents Chemother 2011; 55:5122–5126 [View Article][PubMed]
     [Google Scholar]
  11. Bamberger DM, Boyd SE. Management of Staphylococcus aureus Infections. Am Fam Phys 2005; 72:2474–2481
     [Google Scholar]
  12. Fowler VG, Boucher HW, Corey GR, Abrutyn E, Karchmer AW et al. Daptomycin versus standard therapy for bacteremia and endocarditis caused by Staphylococcus aureus . N Engl J Med 2006; 355:653–665 [View Article][PubMed]
     [Google Scholar]
  13. Forrest GN, Tamura K. Rifampin combination therapy for nonmycobacterial infections. Clin Microbiol Rev 2010; 23:14–34 [View Article][PubMed]
     [Google Scholar]
  14. Forsblom E, Ruotsalainen E, Järvinen A. Improved outcome with early rifampicin combination treatment in methicillin-sensitive Staphylococcus aureus bacteraemia with a deep infection focus – a retrospective cohort study. PLoS One 2015; 10:e0122824 [View Article][PubMed]
     [Google Scholar]
  15. Abraham J, Mansour C, Veledar E, Khan B, Lerakis S. Staphylococcus aureus bacteremia and endocarditis: the Grady Memorial Hospital experience with methicillin-sensitive S aureus and methicillin-resistant S aureus bacteremia. Am Heart J 2004; 147:536–539 [View Article][PubMed]
     [Google Scholar]
  16. Chang FY, Macdonald BB, Peacock JE, Musher DM, Triplett P et al. A prospective multicenter study of Staphylococcus aureus bacteremia: incidence of endocarditis, risk factors for mortality, and clinical impact of methicillin resistance. Medicine 2003; 82:322–332 [View Article][PubMed]
     [Google Scholar]
  17. Wertheim HF, Vos MC, Ott A, van Belkum A, Voss A et al. Risk and outcome of nosocomial Staphylococcus aureus bacteraemia in nasal carriers versus non-carriers. Lancet 2004; 364:703–705 [View Article][PubMed]
     [Google Scholar]
  18. von Eiff C, Becker K, Machka K, Stammer H, Peters G. Nasal carriage as a source of Staphylococcus aureus bacteremia. Study Group. N Engl J Med 2001; 344:11–16 [View Article][PubMed]
     [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/jmm.0.000644
Loading
Disseminated methicillin-susceptible Staphylococcus aureus infection
J. Med. Microbiol. 67, 83 (2018); https://doi.org/10.1099/jmm.0.000644
/content/journal/jmm/10.1099/jmm.0.000644
/content/journal/jmm/10.1099/jmm.0.000644
Loading

Data & Media loading...

Most cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error