@article{mbs:/content/journal/jmm/10.1099/jmm.0.000649, author = "Simonetti, Oriana and Morroni, Gianluca and Ghiselli, Roberto and Orlando, Fiorenza and Brenciani, Andrea and Xhuvelaj, Ledia and Provinciali, Mauro and Offidani, Annamaria and Guerrieri, Mario and Giacometti, Andrea and Cirioni, Oscar", title = "In vitro and in vivo activity of fosfomycin alone and in combination with rifampin and tigecycline against Gram-positive cocci isolated from surgical wound infections", journal= "Journal of Medical Microbiology", year = "2018", volume = "67", number = "1", pages = "139-143", doi = "https://doi.org/10.1099/jmm.0.000649", url = "https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.000649", publisher = "Microbiology Society", issn = "1473-5644", type = "Journal Article", keywords = "Gram-positive cocci", keywords = "Wound infection", keywords = "antimicrobial agents", keywords = "fosfomycin", keywords = "synergy", abstract = "Complicated skin and soft tissue infections constitute a heterogeneous group of severe disorders, with surgical site infections being the most common hospital-acquired ones. The aim of our study was to investigate the synergistic and bactericidal activities of antimicrobial combinations of fosfomycin with rifampicin and tigecycline against Enterococcus faecalis, Enterococcus faecium and methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates, and also to evaluate their in vivo effects in a mouse wound infection model. In in vitro studies, the combinations of fosfomycin with rifampicin and tigecycline were both synergistic. These synergies were confirmed in in vivo studies: the drug combinations showed the highest antimicrobial effects compared to monotherapy. In conclusion, the efficacy of fosfomycin combinations, also confirmed in our in vivo model, may suggest new directions in the treatment of infected skin and a possible alternative way to control bacterial skin infection.", }