1887

Journal of Medical Microbiology logo

Volume 67, Issue 2

Comparative activity of tedizolid and glycopeptide combination therapies for the treatment of infections: an and evaluation against strains with reduced susceptibility to glycopeptides Free

Abstract

Glycopeptides are widely used for the treatment of meticillin-resistant (MRSA) infections. Although difficult to detect, isolates with reduced (GISA), hetero (hGISA) or complete (GRSA) resistance to glycopeptides are increasingly reported. Optimal therapy for such strains is unknown. We compared the and activity of tedizolid (TED), a recently licensed oxazolidonone, with vancomycin (VAN) and teicoplanin (TEIC) combined with fusidic acid (FD) or rifampicin (RIF) against (SA) with reduced susceptibility to glycopeptides.

Susceptibility was determined for six (GISA, hGISA and GRSA) reference strains and 72 clinical MRSA isolates screened for hGISA/GISA-like phenotypes. Synergy and bactericidal activity were assessed using chequerboard and time-kill assays. The wax moth caterpillar model was used to measure the activity of TED and the combinations .

Glycopeptide MICs (VAN/TEIC) ranged from 0.5–8/4 and 0.125–1 for TED. No significant synergy was noted when VAN/TEIC were combined with either RIF or FD. Time-kill assays confirmed that TED was bacteriostatic but superior to VAN and TEIC against GISA strains. In TED was more effective than TEIC monotherapy versus GISA strains. The combination of TEIC with RIF was the most effective combination overall, both and .

TED had good activity versus MRSA including those with reduced susceptibility to glycopeptides. Although bacteriostatic, it was effective in the model and superior to TEIC in the treatment of GISA. Although this supports the use of TED for MRSA and GISA, the TEIC/RIF combination also warrants further study.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): antibiotic combinations , glycopeptide resistance and tedizolid
© 2018 The Authors
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2018-02-01
2024-04-19
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Comparative activity of tedizolid and glycopeptide combination therapies for the treatment of Staphylococcus aureus infections: an in vitro and in vivo evaluation against strains with reduced susceptibility to glycopeptides
J. Med. Microbiol. 67, 265 (2018); https://doi.org/10.1099/jmm.0.000671
/content/journal/jmm/10.1099/jmm.0.000671
/content/journal/jmm/10.1099/jmm.0.000671
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