@article{mbs:/content/journal/jmm/10.1099/jmm.0.000685, author = "Gorla, Maria Cecília and Cassiolato, Ana Paula and Pinhata, Juliana Maira Watanabe and de Moraes, Camile and Corso, Alejandra and Gagetti, Paula and Lemos, Ana Paula", title = "Emergence of resistance to ciprofloxacin in Neisseria meningitidis in Brazil", journal= "Journal of Medical Microbiology", year = "2018", volume = "67", number = "3", pages = "286-288", doi = "https://doi.org/10.1099/jmm.0.000685", url = "https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.000685", publisher = "Microbiology Society", issn = "1473-5644", type = "Journal Article", keywords = "antimicrobial susceptibility", keywords = "meningococcal surveillance", keywords = "Ciprofloxacin", abstract = "To prevent secondary invasive meningococcal disease (IMD) cases and outbreaks, antimicrobial prophylaxis of high-risk contacts is indicated. This study reports two ciprofloxacin-resistant Neisseria meningitidis strains in Brazil. The 3523 N. meningitidis isolates collected throughout Brazil from 2009 to 2016 were evaluated for antimicrobial resistance. Meningococcal isolates showing minimal inhibitory concentrations, MICs≥0.125µg ml−1 to ciprofloxacin, were analysed to determine the presence of mutations in the quinolone resistance-determining regions (QRDRs) of gyrA and parC genes. Two ciprofloxacin-resistant N. meningitidis isolates were found, both presenting a single mutation in the quinolone resistance-determining region of the gyrA gene. These results confirmed that ciprofloxacin is still a first-line drug for chemoprophylaxis. However, we highlight the importance of continued surveillance to monitor the trends of N. meningitidis susceptibility profiles to the antimicrobials recommended for chemoprophylaxis and IMD treatment.", }