%0 Journal Article %A Gorla, Maria Cecília %A Cassiolato, Ana Paula %A Pinhata, Juliana Maira Watanabe %A de Moraes, Camile %A Corso, Alejandra %A Gagetti, Paula %A Lemos, Ana Paula %T Emergence of resistance to ciprofloxacin in Neisseria meningitidis in Brazil %D 2018 %J Journal of Medical Microbiology, %V 67 %N 3 %P 286-288 %@ 1473-5644 %R https://doi.org/10.1099/jmm.0.000685 %K antimicrobial susceptibility %K meningococcal surveillance %K Ciprofloxacin %I Microbiology Society, %X To prevent secondary invasive meningococcal disease (IMD) cases and outbreaks, antimicrobial prophylaxis of high-risk contacts is indicated. This study reports two ciprofloxacin-resistant Neisseria meningitidis strains in Brazil. The 3523 N. meningitidis isolates collected throughout Brazil from 2009 to 2016 were evaluated for antimicrobial resistance. Meningococcal isolates showing minimal inhibitory concentrations, MICs≥0.125µg ml−1 to ciprofloxacin, were analysed to determine the presence of mutations in the quinolone resistance-determining regions (QRDRs) of gyrA and parC genes. Two ciprofloxacin-resistant N. meningitidis isolates were found, both presenting a single mutation in the quinolone resistance-determining region of the gyrA gene. These results confirmed that ciprofloxacin is still a first-line drug for chemoprophylaxis. However, we highlight the importance of continued surveillance to monitor the trends of N. meningitidis susceptibility profiles to the antimicrobials recommended for chemoprophylaxis and IMD treatment. %U https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.000685