RT Journal Article SR Electronic(1) A1 Dafopoulou, K. A1 Tsakris, A. A1 Pournaras, S.YR 2018 T1 Changes in antimicrobial resistance of clinical isolates of Acinetobacter baumannii group isolated in Greece, 2010–2015 JF Journal of Medical Microbiology, VO 67 IS 4 SP 496 OP 498 DO https://doi.org/10.1099/jmm.0.000708 PB Microbiology Society, SN 1473-5644, AB In recent years, hospitals in southeastern Europe have faced dramatically high rates of antibiotic-resistant Acinetobacter baumannii. We analysed the evolution of resistance among clinical isolates of A. baumannii group obtained from nine tertiary hospitals throughout Greece over 6 years (2010–2015). Identification and antimicrobial susceptibility testing were performed using Vitek 2 or Microscan walkaway automated systems. Between 2010 and 2015, resistance to ampicillin/sulbactam increased from 46.2 to 88.2 % (P=0.021), resistance to gentamicin increased from 69.3 to 86.4 % (P=0.014) and resistance to tobramycin increased from 59.8 to 76.8 % (P=0.011). Imipenem resistance rates were consistently very high, ranging from 90.3 % in 2010 to 94.5 % in 2015 (P=0.198), while meropenem resistance rates increased from 82.6 % in 2010 to 94.8 % in 2015 (P=0.006). Resistance rates to trimethoprim/sulfamethoxazole showed a remarkable decreasing trend, declining from 90.2 % in 2010 to 69.1 % in 2015 (P=0.035). These evolutions render the treatment of A. baumannii infections particularly challenging and underline the need for enhanced infection control measures., UL https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.000708