1887

Abstract

In traditional Korean medicine, H. (ART) and G. (SCU) are combined for the treatment of malaria and other malaria-like diseases. Because SCU is well-known as an antibacterial agent, the antimicrobial effect of a mixture of ART and SCU was investigated.

Plant samples were purchased from Kyungdong mart and extracted with 70 % ethanol. The antimicrobial activity of ART and SCU against pathogenic fungi (, and ), Gram-negative bacteria ( and ) and Gram-positive bacteria ( and ) was evaluated using a broth microdilution assay, modified-disc diffusion and agar dilution methods with further CHCl-fractionated ART, SCU and a mixture of ART/SCU (at a ratio of 3 : 5) (THAN-1).

ART and SCU were effective against , , and . The range of minimum inhibitory concentration (MIC) values was 0.03125 to 4 mg ml in the ART and SCU treatments. ART exhibited stronger activity than SCU. Interestingly, a 3 : 5 ratio mixture of ART and SCU (THAN-1) showed stronger antimicrobial activity than ART or SCU used individually.

A treatment using a mixture of herbs such as THAN-1 would be useful in the suppression of the growth of pathogenic bacterial and fungal strains.

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2018-04-01
2024-03-28
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