%0 Journal Article %A Uchida, Hiroki %A Tada, Tatsuya %A Sugahara, Yoshie %A Kato, Akira %A Miyairi, Isao %A Kirikae, Teruo %T A clinical isolate of Escherichia coli co-harbouring mcr-1 and blaNDM-5 in Japan %D 2018 %J Journal of Medical Microbiology, %V 67 %N 8 %P 1047-1049 %@ 1473-5644 %R https://doi.org/10.1099/jmm.0.000793 %K Mcr-1 %K colistin resistance %K CRE %K NDM-5 %I Microbiology Society, %X The mcr-1 gene encodes a phosphoethanolamine transferase, which confers resistance to colistin by transferring phosphoethanolamine to lipid A. This study describes the emergence of a colistin- and carbapenem-resistant clinical isolate of Escherichia coli harbouring mcr-1 and bla NDM-5 genes, located on 90 and 150 Kb plasmids, respectively. The isolate belonged to ST132. This is the first report of a clinical isolate in Japan co-harbouring mcr-1 and bla NDM-5. %U https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.000793