1887

Abstract

We have identified a Salmonella enterica serotype 4,[5],12:i:- containing a mcr-3.2 in a patient who travelled to Thailand 1 month prior to the identification of it in Canada. The isolate was multidrug resistant, but remained susceptible to the carbapenems, amikacin and piperacillin/tazobactam. The mcr-3.2 was carried on a 261 Kb variant of the IncHI2 pWJ1. This report provides further evidence of the emergence of a ST34 colistin-resistant clone.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/jmm.0.000854
2018-10-23
2024-04-16
Loading full text...

Full text loading...

/deliver/fulltext/jmm/67/12/1673.html?itemId=/content/journal/jmm/10.1099/jmm.0.000854&mimeType=html&fmt=ahah

References

  1. Schwarz S, Johnson AP. Transferable resistance to colistin: a new but old threat. J Antimicrob Chemother 2016; 71:2066–2070 [View Article][PubMed]
    [Google Scholar]
  2. Liu YY, Wang Y, Walsh TR, Yi LX, Zhang R et al. Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study. Lancet Infect Dis 2016; 16:161–168 [View Article][PubMed]
    [Google Scholar]
  3. Xavier BB, Lammens C, Ruhal R, Kumar-Singh S, Butaye P et al. Identification of a novel plasmid-mediated colistin-resistance gene, mcr-2, in Escherichia coli, Belgium, June 2016. Eurosurveillance 2016; 21:pii 30280 [View Article]
    [Google Scholar]
  4. Yin W, Li H, Shen Y, Liu Z, Wang S et al. Novel plasmid-mediated colistin resistance gene mcr-3 in Escherichia coli. mBio 2017; 8:e0054317 [View Article][PubMed]
    [Google Scholar]
  5. Carattoli A, Villa L, Feudi C, Curcio L, Orsini S et al. Novel plasmid-mediated colistin resistance mcr-4 gene in Salmonella and Escherichia coli, Italy 2013, Spain and Belgium, 2015 to 2016. Euro Surveill 2017; 22:pii=30589 [View Article][PubMed]
    [Google Scholar]
  6. Borowiak M, Fischer J, Hammerl JA, Hendriksen RS, Szabo I et al. Identification of a novel transposon-associated phosphoethanolamine transferase gene, mcr-5, conferring colistin resistance in d-tartrate fermenting Salmonella enterica subsp. enterica serovar Paratyphi B. J Antimicrob Chemother 2017; 72:3317–3324 [View Article][PubMed]
    [Google Scholar]
  7. Wang X, Wang Y, Zhou Y, Li J, Yin W et al. Emergence of a novel mobile colistin resistance gene, mcr-8, in NDM-producing Klebsiella pneumoniae. Emerg Microbes Infect 2018; 7:122 [View Article][PubMed]
    [Google Scholar]
  8. Hernández M, Iglesias MR, Rodríguez-Lázaro D, Gallardo A, Quijada N et al. Co-occurrence of colistin-resistance genes mcr-1 and mcr-3 among multidrug-resistant Escherichia coli isolated from cattle, Spain, September 2015. Eurosurveillance 2017; 22:pii=30586 [View Article]
    [Google Scholar]
  9. Roer L, Hansen F, Stegger M, Sönksen UW, Hasman H et al. Novel mcr-3 variant, encoding mobile colistin resistance, in an ST131 Escherichia coli isolate from bloodstream infection, Denmark, 2014. Eurosurveillance 2017; 22:pii=30584 [View Article]
    [Google Scholar]
  10. Litrup E, Kiil K, Hammerum AM, Roer L, Nielsen EM et al. Plasmid-borne colistin resistance gene mcr-3 in Salmonella isolates from human infections, Denmark, 2009–17. Eurosurveillance 2017; 22:30587–30593 [View Article]
    [Google Scholar]
  11. Arnott A, Wang Q, Bachmann N, Sadsad R, Biswas C et al. Multidrug-resistant Salmonella enterica 4,[5],12:i:- Sequence Type 34, New South Wales, Australia, 2016–2017. Emerg Infect Dis 2018; 24:751–753 [View Article]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/jmm.0.000854
Loading
/content/journal/jmm/10.1099/jmm.0.000854
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error