Clinical features and microbiological characteristics of hospital- and community-onset Escherichia coli bloodstream infection
Chen, Xiao and Zou, Qianda and Zhang, Weili and Wang, Ruonan and Yu, Fei and Chen, Yu,, 68, 178-187 (2019),
doi = https://doi.org/10.1099/jmm.0.000904,
publicationName = Microbiology Society,
issn = 0022-2615,
abstract= Purpose. Escherichia coli is a leading cause of bloodstream infection (BSI) in hospitals and communities. Methodology. We conducted a retrospective study in 2015 to evaluate the clinical features and microbiological characteristics of E. coli BSI acquired in the hospital and community. Results. A total of 100 patients with E. coli BSI were enrolled, among whom 60 % had hospital-onset (HO) BSI while 40 % had community-onset (CO) BSI. Patients with HO BSI had higher percentages of haematological disorders, immunosuppression conditions, underwent surgery within 2 weeks and had a higher 30-day mortality. The prevalences of multidrug-resistant and extended-spectrum β-lactamase-producing strains were 81 and 60 %, respectively. Resistance percentages to ampicillin, ampicillin-sulbactam, cefazolin, ceftriaxone, ciprofloxacin and levofloxacin were greater than 50 %. Of the 43 different sequence types (STs) identified, ST131 (15.3 %) was the most common. The serum agglutination rate was 52 % in which 13 O and 11 H serogroups were observed. Among the 36 detected virulence factor (VF) genes, IutA (66 %) and traT (61 %) were the most predominant. papA, papC and papEF were different between the CO and HO BSI groups. VF scores were high (mean >7) in the frequently detected ST95, ST1193 and ST131. Conclusion. This study revealed that the clinical features of HO and CO E. coli BSI were different. STs and serotypes showed a great diversity in this region while VF genes of the isolates varied between clones.,
language=,
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