1887

Abstract

In this study, we differentiated between tuberculosis (TB) and infections caused by nontuberculous mycobacteria (NTM) or in a tertiary general hospital in China. Differences in clinical manifestations and factors between respiratory infections associated with these organisms were also investigated.

A retrospective analysis was conducted for suspected pulmonary TB patients with positive bacterial culture results under treatment at Wangjing Hospital, a tertiary general hospital, between January 2014 and June 2017. Sputum samples were submitted for liquid culture and species identification by mass spectrometry.

Between January 2014 and June 2017, a total of 3981 suspected TB cases were analysed, of which 151 (3.8 %) exhibited positive mycobacterial culture results. Using mass spectrometry, the 151 isolates were classified into three groups: (MTB) (=112; 74.2 %), NTM (=21 13.9 %) and (=18; 11.9 %). The NTM and prevalence rates were significantly higher amongst elderly patients [aged ≥65 years; odds ratio (95 % confidence interval): 3.89 (1.05–14.38) for NTM; odds ratio (95 % confidence interval): 5.10 (1.09–23.91) for ]. In addition, treatment with immunosuppressive therapy [odds ratio (95 % confidence interval): 3.92 (1.16–13.27)] was identified as a risk factor for infection in these patients.

Our results demonstrated that a quarter of culture-positive ‘suspected TB patients’ harboured NTM or infections. Notably, nearly all patients with non-TB infections presented with clinical syndromes mimicking pulmonary TB. Individuals receiving immunosuppressive therapy were at greater risk of acquiring infections.

Funding
This study was supported by the:
  • Beijing Municipal Administration of Hospitals’ Youth Programme (Award QML20171601)
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2019-04-25
2024-04-19
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