%0 Journal Article %A Nakaminami, Hidemasa %A Takadama, Shunsuke %A Okita, Miki %A Sasaki, Mari %A Noguchi, Norihisa %T Fast-acting bactericidal activity of olanexidine gluconate against qacA/B-positive methicillin-resistant Staphylococcus aureus %D 2019 %J Journal of Medical Microbiology, %V 68 %N 6 %P 957-960 %@ 1473-5644 %R https://doi.org/10.1099/jmm.0.000979 %K qacA/B-positive methicillin-resistant Staphylococcus aureus %K fast-acting bactericidal activity %K olanexidine %I Microbiology Society, %X The qacA/B gene is one of the major determinants of resistance to antiseptics in methicillin-resistant Staphylococcus aureus (MRSA). Here, we compared the fast-acting bactericidal activity of skin antiseptics, including olanexidine gluconate (OLG), a new biguanide antiseptic agent introduced in Japan, against clinical qacA/B-positive MRSA strains by determination of minimum bactericidal concentration and time–kill assay. Our findings provide, for the first time, data indicating that the fast-acting bactericidal activity of OLG against qacA/B-positive MRSA is higher than that of chlorhexidine gluconate, even though both are biguanide antiseptics. %U https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.000979