Fast-acting bactericidal activity of olanexidine gluconate against qacA/B-positive methicillin-resistant Staphylococcus aureus
Nakaminami, Hidemasa and Takadama, Shunsuke and Okita, Miki and Sasaki, Mari and Noguchi, Norihisa,, 68, 957-960 (2019),
doi = https://doi.org/10.1099/jmm.0.000979,
publicationName = Microbiology Society,
issn = 0022-2615,
abstract= The qacA/B gene is one of the major determinants of resistance to antiseptics in methicillin-resistant Staphylococcus aureus (MRSA). Here, we compared the fast-acting bactericidal activity of skin antiseptics, including olanexidine gluconate (OLG), a new biguanide antiseptic agent introduced in Japan, against clinical qacA/B-positive MRSA strains by determination of minimum bactericidal concentration and time–kill assay. Our findings provide, for the first time, data indicating that the fast-acting bactericidal activity of OLG against qacA/B-positive MRSA is higher than that of chlorhexidine gluconate, even though both are biguanide antiseptics.,
language=,
type=