High prevalence of plasmid-mediated quinolone resistance determinants in commensal members of the Enterobacteriaceae in Ho Chi Minh City, Vietnam Minh Vien, Le Thi and Baker, Stephen and Phuong Thao, Le Thi and Phuong Tu, Le Thi and Thu Thuy, Cao and Thu Nga, Tran Thi and Minh Hoang, Nguyen Van and Campbell, James Iain and Minh Yen, Lam and Trong Hieu, Nguyen and Vinh Chau, Nguyen Van and Farrar, Jeremy and Schultsz, Constance,, 58, 1585-1592 (2009), doi = https://doi.org/10.1099/jmm.0.010033-0, publicationName = Microbiology Society, issn = 0022-2615, abstract= Antimicrobial-resistant pathogenic members of the Enterobacteriaceae are a well-defined global problem. We hypothesized that one of the main reservoirs of dissemination of antimicrobial resistance genes in Vietnam is non-pathogenic intestinal flora, and sought to isolate antimicrobial-resistant organisms from hospitalized patients and non-hospitalized healthy individuals in Ho Chi Minh City. The results identified substantial faecal carriage of gentamicin-, ceftazidime- and nalidixic acid-resistant members of the Enterobacteriaceae in both hospitalized patients and non-hospitalized healthy individuals. A high prevalence of quinolone resistance determinants was identified, particularly the qnrS gene, in both community- and hospital-associated strains. Furthermore, the results demonstrated that a combination of quinolone resistance determinants can confer resistance to nalidixic acid and ciprofloxacin, even in the apparent absence of additional chromosomal resistance mutations in wild-type strains and laboratory strains with transferred plasmids. These data suggest that intestinal commensal organisms are a significant reservoir for the dissemination of plasmid-mediated quinolone resistance in Ho Chi Minh City., language=, type=