RT Journal Article SR Electronic(1) A1 Minh Vien, Le Thi A1 Baker, Stephen A1 Phuong Thao, Le Thi A1 Phuong Tu, Le Thi A1 Thu Thuy, Cao A1 Thu Nga, Tran Thi A1 Minh Hoang, Nguyen Van A1 Campbell, James Iain A1 Minh Yen, Lam A1 Trong Hieu, Nguyen A1 Vinh Chau, Nguyen Van A1 Farrar, Jeremy A1 Schultsz, ConstanceYR 2009 T1 High prevalence of plasmid-mediated quinolone resistance determinants in commensal members of the Enterobacteriaceae in Ho Chi Minh City, Vietnam JF Journal of Medical Microbiology, VO 58 IS 12 SP 1585 OP 1592 DO https://doi.org/10.1099/jmm.0.010033-0 PB Microbiology Society, SN 1473-5644, AB Antimicrobial-resistant pathogenic members of the Enterobacteriaceae are a well-defined global problem. We hypothesized that one of the main reservoirs of dissemination of antimicrobial resistance genes in Vietnam is non-pathogenic intestinal flora, and sought to isolate antimicrobial-resistant organisms from hospitalized patients and non-hospitalized healthy individuals in Ho Chi Minh City. The results identified substantial faecal carriage of gentamicin-, ceftazidime- and nalidixic acid-resistant members of the Enterobacteriaceae in both hospitalized patients and non-hospitalized healthy individuals. A high prevalence of quinolone resistance determinants was identified, particularly the qnrS gene, in both community- and hospital-associated strains. Furthermore, the results demonstrated that a combination of quinolone resistance determinants can confer resistance to nalidixic acid and ciprofloxacin, even in the apparent absence of additional chromosomal resistance mutations in wild-type strains and laboratory strains with transferred plasmids. These data suggest that intestinal commensal organisms are a significant reservoir for the dissemination of plasmid-mediated quinolone resistance in Ho Chi Minh City., UL https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.010033-0