RT Journal Article SR Electronic(1) A1 Murono, Koichi A1 Hirano, Yoshiki A1 Koyano, Shin A1 Ito, Kiminari A1 Fujieda, KenjiYR 2003 T1 Molecular comparison of bacterial isolates from blood with strains colonizing pharynx and intestine in immunocompromised patients with sepsis JF Journal of Medical Microbiology, VO 52 IS 6 SP 527 OP 530 DO https://doi.org/10.1099/jmm.0.05076-0 PB Microbiology Society, SN 1473-5644, AB Most causative organisms of sepsis in immunocompromised patients are the same species as those that colonize their own nasopharynx or intestinal tract. To determine whether the strains recovered from blood originate mainly from patients’ own flora, isolates from blood and throat and/or stool were investigated by genomic analyses. Surveillance cultures of throat and stool were taken prospectively from cancer patients being treated with intensive chemotherapy followed by haematopoietic stem-cell transplantation. In those cases of sepsis in which the isolate from blood was the same species as that from the throat and/or stool, the genomic profiles of the isolates were compared by PFGE. Ten cases of blood culture-positive sepsis were documented in six of 14 subjects during a 2 year period; isolates of Pseudomonas aeruginosa, Staphylococcus epidermidis, Enterococcus sp., viridans streptococci and Fusobacterium sp. were recovered from blood. In five of seven cases in which the blood isolate was the same species as that from the throat or stool, the genotypes of the isolates from both sites were identical. In the majority of immunocompromised patients, the causative organisms of bloodstream infections originated mainly from their own flora., UL https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.05076-0