@article{mbs:/content/journal/jmm/10.1099/jmm.0.076646-0, author = "Nhu, Nguyen Thi Khanh and Lan, Nguyen Phu Huong and Campbell, James I. and Parry, Christopher M. and Thompson, Corinne and Tuyen, Ha Thanh and Hoang, Nguyen Van Minh and Tam, Pham Thi Thanh and Le, Vien Minh and Nga, Tran Vu Thieu and Nhu, Tran Do Hoang and Van Minh, Pham and Nga, Nguyen Thi Thu and Thuy, Cao Thu and Dung, Le Thi and Yen, Nguyen Thi Thu and Van Hao, Nguyen and Loan, Huynh Thi and Yen, Lam Minh and Nghia, Ho Dang Trung and Hien, Tran Tinh and Thwaites, Louise and Thwaites, Guy and Chau, Nguyen Van Vinh and Baker, Stephen", title = "Emergence of carbapenem-resistant Acinetobacter baumannii as the major cause of ventilator-associated pneumonia in intensive care unit patients at an infectious disease hospital in southern Vietnam", journal= "Journal of Medical Microbiology", year = "2014", volume = "63", number = "10", pages = "1386-1394", doi = "https://doi.org/10.1099/jmm.0.076646-0", url = "https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.076646-0", publisher = "Microbiology Society", issn = "1473-5644", type = "Journal Article", abstract = "Ventilator-associated pneumonia (VAP) is a serious healthcare-associated infection that affects up to 30ā€Š% of intubated and mechanically ventilated patients in intensive care units (ICUs) worldwide. The bacterial aetiology and corresponding antimicrobial susceptibility of VAP is highly variable, and can differ between countries, national provinces and even between different wards in the same hospital. We aimed to understand and document changes in the causative agents of VAP and their antimicrobial susceptibility profiles retrospectively over an 11 year period in a major infectious disease hospital in southern Vietnam. Our analysis outlined a significant shift from Pseudomonas aeruginosa to Acinetobacter spp. as the most prevalent bacteria isolated from quantitative tracheal aspirates in patients with VAP in this setting. Antimicrobial resistance was common across all bacterial species and we found a marked proportional annual increase in carbapenem-resistant Acinetobacter spp. over a 3 year period from 2008 (annual trend; odds ratio 1.656, Pā€Š=ā€Š0.010). We further investigated the possible emergence of a carbapenem-resistant Acinetobacter baumannii clone by multiple-locus variable number tandem repeat analysis, finding a bla OXA-23-positive strain that was associated with an upsurge in the isolation of this pathogen. We additionally identified a single bla NDM-1-positive A. baumannii isolate. This work highlights the emergence of a carbapenem-resistant clone of A. baumannii and a worrying trend of antimicrobial resistance in the ICU of the Hospital for Tropical Diseases in Ho Chi Minh City, Vietnam.", }