Effects of orally administered bovine lactoferrin and lactoperoxidase on influenza virus infection in mice Shin, Kouichirou and Wakabayashi, Hiroyuki and Yamauchi, Koji and Teraguchi, Susumu and Tamura, Yoshitaka and Kurokawa, Masahiko and Shiraki, Kimiyasu,, 54, 717-723 (2005), doi = https://doi.org/10.1099/jmm.0.46018-0, publicationName = Microbiology Society, issn = 0022-2615, abstract= Milk contains a wide variety of host protective factors against infectious microbes. Among these protective factors, lactoferrin (LF) and lactoperoxidase (LPO) have been reported to exhibit antiviral activities as well as immuno-modulatory effects. In the present study, the effects of orally administered LF and LPO were assessed in a mouse influenza virus infection model. BALB/c mice were intranasally infected with 6.6 × 102 p.f.u. of influenza virus A/PR/8/34(H1N1). Bovine LF or LPO was administered once daily at a dose of 62.5 mg per mouse by gavage, starting 1 day before infection. Mice given LF or LPO showed a significantly lower lung consolidation score on day 6 after infection compared with the control mice that were given water instead. Concurrently, the number of infiltrated leukocytes recovered from bronchoalveolar lavage fluid (BALF) on day 6 was significantly lower in mice given LF or LPO. However, the virus yield in the BALF was not affected by these treatments. The serum level of IL-6, a pro-inflammatory cytokine, positively correlated with the lung consolidation score in each group and was significantly lower on day 6 in the mice given LPO. These results suggest the potential of oral administration of LF or LPO to attenuate pneumonia in influenza-virus-infected mice through the suppression of infiltration of inflammatory cells in the lung., language=, type=