%0 Journal Article %A Zhou, Hua %A Pi, Bo-Rui %A Yang, Qing %A Yu, Yun-Song %A Chen, Ya-Gang %A Li, Lan-Juan %A Zheng, Shu-Sen %T Dissemination of imipenem-resistant Acinetobacter baumannii strains carrying the ISAba1–blaOXA-23 genes in a Chinese hospital %D 2007 %J Journal of Medical Microbiology, %V 56 %N 8 %P 1076-1080 %@ 1473-5644 %R https://doi.org/10.1099/jmm.0.47206-0 %K ICU, intensive care unit %I Microbiology Society, %X An outbreak of 95 clinical infections with imipenem-resistant Acinetobacter baumannii in a Chinese hospital was investigated and the carbapenemase-encoding genes and their relationship with ISAba1 of these and a further 16 isolates recovered from the intensive care unit (ICU) environment were analysed. Almost all isolates were resistant to a wide range of antimicrobials; the lowest resistance rates were found for polymyxin E (17.1 %), cefoperazone/sulbactam (30.6 %) and ampicillin/sulbactam (67.6 %). Six pattern types defined by DNA macrorestriction patterns were distinguished among the clinical isolates with dissemination of pattern A (50 isolates) to patients in seven hospital units and pattern B (35 isolates) to eight units; the environmental isolates from ICUs were also of pattern A. All isolates were positive for the bla OXA-66 and bla OXA-23 genes. The OXA-23-encoding gene was located 34 bp downstream of ISAba1. No plasmids were detected and conjugal transfer of resistance was not demonstrated. The bla OXA-23 probe hybridized with 200 and 220 kb ApaI chromosomal fragments for type patterns A and B, respectively. %U https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.47206-0