1887

Journal of Medical Microbiology logo

Volume 10, Issue 2

Effects of Biliary Diversion on Intestinal Microflora in the Rat Free

Abstract

SUMMARY

Certain bile acids inhibit the growth of organisms commonly found in the intestine and, in particular, anaerobic bacteria. As the importance of this effect has not been demonstrated, we investigated changes in intestinal flora in the rat after diversion of bile to the urinary bladder.

Five days after operation there was an increase in numbers of sp. in the stomach, mid-jejunum and caecum and of coliform bacilli in the stomach and mid-jejunum. Lacto-bacilli were increased in the stomach. There was no change in numbers of anaerobic organisms. Similar changes in bacterial flora followed 5 days of pair feeding in control rats. Our results do not suggest a specific antibacterial effect of bile salts in the rat The changes found are probably related to semi-starvation, because the food intake of the rats after operation was about half that of control rats having an unrestricted diet.

  • Received:
  • Accepted:
  • Published Online:
© J. MED. MICROBIOL. 1977
Loading

Article metrics loading...

/content/journal/jmm/10.1099/00222615-10-2-241
1977-05-01
2024-05-01
Loading full text...

Full text loading...

/deliver/fulltext/jmm/10/2/medmicro-10-2-241.html?itemId=/content/journal/jmm/10.1099/00222615-10-2-241&mimeType=html&fmt=ahah

References

  1. Brown W. R., Newcombe R. W., Ishizaka K. 1970; Proteolytic degradation of exocrine and serum immunoglobulins. J. clin. Invest 49:1374
     [Google Scholar]
  2. Man J. C. de, Rogosa M., Sharpe M. E. 1960; A medium for the cultivation of lactobacilli. J. Appl. Bact 23:130
     [Google Scholar]
  3. Dixon J. M. S. 1960; The fate of bacteria in the small intestine. J. Path. Bact 79:131
     [Google Scholar]
  4. Drasar B. S., Shiner M., McLeod G. M. 1969; Studies on the intestinal flora. I. The bacterial flora of the gastrointestinal tract in healthy and achlorhydric persons. Gastroenterology 56:71
     [Google Scholar]
  5. Floch M. H., Gershengoren W., Elliott S., Spiro H. M. 1971; Bile acid inhibition of the intestinal microflora—a function of simple bile acids?. Gastroenterology 61:228
     [Google Scholar]
  6. Goldsworthy N. E., Florey H. 1930; Some properties of mucus with special reference to its antibacterial functions. Br. J. exp. Path 11:192
     [Google Scholar]
  7. Griffen W. O., Richardson I. D., Medley E. 1971; Prevention of small bowel contamination by ileocaecal valve. Sth Afr. med. J 64:1056
     [Google Scholar]
  8. Meynell G. G. 1963; Antibacterial mechanisms of the mouse gut. II. The role of Eh and volatile fatty acids in the normal gut. Br. J. exp. Path 44:209
     [Google Scholar]
  9. Sacquet E., Raibaud P., Garnier J. 1971; Etude comparee de la microflore de l’estomac, de l’intestin grele et du caecum du rat “ holoxenique ” (conventionnel), et de ses modifications a la suite de diverses interventions chirurgicales: anse aveugle jéjunale, deviations biliaires. Annls Inst. Pasteur, Paris 120:501
     [Google Scholar]
  10. Stacey M., Webb M. 1947; Studies on the antibacterial properties of the bile acids and some compounds derived from cholanic acid. Proc. Roy. Soc. B 134:523
     [Google Scholar]
  11. Williams R. C., Showalter R., Kern F. Jr 1975; In vivo effect of bile salts and cholestyramine on intestinal anaerobic bacteria. Gastroenterology 69:483
     [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/00222615-10-2-241
Loading
Effects of Biliary Diversion on Intestinal Microflora in the Rat
J. Med. Microbiol. 10, 241 (1977); https://doi.org/10.1099/00222615-10-2-241
/content/journal/jmm/10.1099/00222615-10-2-241
/content/journal/jmm/10.1099/00222615-10-2-241
Loading

Data & Media loading...

Most cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error