1887

Abstract

SUMMARY

Three capsulate pneumococcal strains of serotypes 1, 2 and 3, and one non-capsulate strain of serotype 47, were found to activate human complement by the alternative pathway to a similar extent over the concentration range examined. Nevertheless, the capsulate strains, in contrast to the non-capsulate, are known to require complement attachment for phagocytosis and it is therefore postulated that the toxic by-products released cause the wave of oedema characteristic of pneumococcal lobar pneumonia.

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/content/journal/jmm/10.1099/00222615-11-1-7
1978-02-01
2024-05-05
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References

  1. Allison A. C., Schorlemmer H. U., Bitter-Suermann D. 1976; Activation of complement by the alternative pathway as a factor in the pathogenesis of periodontal disease. Lancet 2:1001
    [Google Scholar]
  2. Cochrane C. G., Müller-Eberhard H. J. 1968; The derivation of two distinct anaphylatoxin activities from the third and fifth components of human complement. J. exp. Med 127:371
    [Google Scholar]
  3. Dias Da Silva W., Lepow I. H. 1967; Complement as a mediator of inflammation. II. Biological properties of anaphylatoxin prepared with purified components of human complement. J. exp. Med 125:921
    [Google Scholar]
  4. Fearon D. T., Ruddy S., Schur P. H., Mccabe W. R. 1975; Activation of the properdin pathway of complement in patients with Gram-negative bacteremia. N. Engl. J. Med 292:937
    [Google Scholar]
  5. Fine D. P. 1975; Pneumococcal type-associated variability in alternate complement pathway activation. Infect. Immun 12:772
    [Google Scholar]
  6. Fine D. P., Marney S. R. Jr, Colley D. G., Sergent J. S., Des Prez R. M. 1972; C3 shunt activation in human serum chelated with EGTA. J. Immun 109:807
    [Google Scholar]
  7. Greenwood B. M., Brueton M. J. 1974; Complement activation in children with acute malaria. Clin. exp. 18:267
    [Google Scholar]
  8. Greenwood B. M., Onyewotu I. I., Whittle H. C. 1976; Complement and meningococcal infection. Br. med. J 1:797
    [Google Scholar]
  9. Johnson U., Laurell A. 1975; Complement activation in meningococcal septicaemia. Acta path, microbiol. scand C83:285
    [Google Scholar]
  10. Lachmann P. J., Hobart M. J., Aston W. P. 1973; Complement technology. In Handbook of experimental immunology 2nd ed., edited by Weir D. M. Oxford, London, Edinburgh and Melbourne: vol 1: chapter 5
    [Google Scholar]
  11. Laurell C. B., Lundh B. 1967; Electrophoretic studies of the conversion products of serum β1c-globulin. Immunology 12:313
    [Google Scholar]
  12. Laurell C. B. 1965; Antigen-antibody crossed electrophoresis. Analyt. Biochem 10:358
    [Google Scholar]
  13. Laurell C. B. 1966; Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies. Analyt. Biochem 15:45
    [Google Scholar]
  14. Pryjma J., Humphrey J. H., Klaus G. G. B. 1974; C3 activation and independent B cell stimulation. Nature, Lond 252:505
    [Google Scholar]
  15. Reed W. P., Davidson M. S., Williams R. C. 1976; Complement system in pneumococcal infections. Infect. Immun 13:1120
    [Google Scholar]
  16. Sandberg A. L., Osler A. G. 1971; Dual pathways of complement interaction with guinea pig immunoglobulins. J. Immun 107:1268
    [Google Scholar]
  17. Shin H. S., Smith M. R., Wood W. B. Jr 1969; Heat labile opsonins to pneumococcus. II. Involvement of C3 and C5. J. exp. Med 130:1229
    [Google Scholar]
  18. Smith M. R., Wood W. B. Jr 1969; Heat labile opsonins to pneumococcus. I. Participation of complement. J. exp. Med 130:1209
    [Google Scholar]
  19. Ward P. A., Cochrane C. G., Müller-Eberhard H. J. 1966; Further studies on the chemotactic factor of complement and its formation in vivo. Immunology 11:141
    [Google Scholar]
  20. Winkelstein J. A., Bocchini J. A. Jr, Schiffman G. 1976; The role of the capsular polysaccharide in the activation of the alternative pathway by the pneumococcus. J. Immun 116:367
    [Google Scholar]
  21. Wood W. B. Jr, Smith M. R. 1949; The inhibition of surface phagocytosis by the capsular “slime layer” of pneumococcus Type III. J. exp. Med 90:85
    [Google Scholar]
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