1887

Abstract

SUMMARY

The virulence of six strains of staphylococci in experimental subcutaneous infection in mice of three age groups (3, 10 and 21 days) was studied. The results showed an age-related susceptibility to infection, in that the newborn mice were more susceptible than older mice to death and lesion formation. Resistance, i.e., ability to survive challenge of 10 c.f.u., developed at about 5 days. The strains used varied in toxin and enzyme pattern and there were marked differences in response to challenge as measured by mortality and lesion development. The strain was least virulent, while some strains of S. aureus produced lesions at low doses (10 c.f.u.). Two distinct types of lesion were observed, abscesses and necrotic lesions. Development of necrotic lesions appeared to be correlated with the ability to produce toxin .

Loading

Article metrics loading...

/content/journal/jmm/10.1099/00222615-12-1-99
1979-02-01
2024-05-07
Loading full text...

Full text loading...

/deliver/fulltext/jmm/12/1/medmicro-12-1-99.html?itemId=/content/journal/jmm/10.1099/00222615-12-1-99&mimeType=html&fmt=ahah

References

  1. Agarwal D. S. 1967a; Subcutaneous staphylococcal infection in mice. I. The role of cotton dust in enhancing infection. Br. J. exp. Path 48:436
    [Google Scholar]
  2. Agarwal D. S. 1967b; Subcutaneous staphylococcal infection in mice. II. The inflammatory response to different strains of staphylococci and micrococci. Br. J. exp. Path 48:468
    [Google Scholar]
  3. Agarwal D. S. 1967c; Subcutaneous staphylococcal infection in mice. III. Effect of active and passive immunization and anti-inflammatory drugs. Br. J. exp. Path 48:483
    [Google Scholar]
  4. Anderson J. C. 1971; Observations on mouse mastitis produced by inoculation of different strains of staphylococcus. Res. vet. Sci 12:186
    [Google Scholar]
  5. Anderson J. C. 1974; Experimental staphylococcal mastitis in the mouse: effects of extracellular products and whole bacterial cells from a high-virulence and a low-virulence strain of Staphylococcus aureus. J. med. Microbiol 7:205
    [Google Scholar]
  6. Arbuthnott J. P., Gemmell C. G., Kent J., Lyell A. 1969; Haemolysin and enzyme patterns of coagulase-positive staphylococci isolated from toxic epidermal necrolysis, Ritter’s disease and impetigo contagiosa. J. med. Microbiol 2:479
    [Google Scholar]
  7. Arbuthnott J. P., Kent J., Lyell A., Gemmell C. G. 1971; Toxic epidermal necrolysis produced by an extracellular product of Staphylococcus aureus. Br. J. Dermatol 85:145
    [Google Scholar]
  8. Chesbro W., Taylor N., Smith M. 1972; Relationships between host origin of staphylococcal strains and their virulence for mice. Can. J. Microbiol 18:1371
    [Google Scholar]
  9. Easmon C. S. F., Glynn A. A. 1975a; The role of humoral immunity and acute inflammation in protection against staphylococcal dermonecrosis. Immunology 29:67
    [Google Scholar]
  10. Easmon C. S. F., Glynn A. A. 1975b; Cell-mediated immune response in Staph, aureus infections in mice. Immunology 29:75
    [Google Scholar]
  11. Easmon C. S. F., Glynn A. A. 1976a; Comparison of subcutaneous and intraperitoneal staphylococcal infections in normal and complement-deficient mice. Infect. Immun 13:399
    [Google Scholar]
  12. Easmon C. S. F., Glynn A. A. 1976b; Cell mediated hypersensitivity in staphylococcal skin infection in mice and its relationship to the human response. In Staphylococci and staphylococcal diseases edited by Jeljaszewicz, J. Stuttgart: p 895
    [Google Scholar]
  13. Foster E. A. 1967; Tissue injury by toxins in experimental staphylococcal infections: effect of polyvalent antitoxin on developing renal lesions. Am. J. Path 51:913
    [Google Scholar]
  14. Gladstone G. P., van Heyningen W. E. 1957; Staphylococcal leucocidins. Br. J. exp. Path 38:123
    [Google Scholar]
  15. Gladstone G. P., Mudd S., Hochstein H. D., Lenhart N. A. 1962; The assay of anti-staphylococcal leucocidal components (F and S) in human serum. Br. J. exp. Path 43:295
    [Google Scholar]
  16. Hill M. J. 1968; A staphylococcal aggressin. J. med. Microbiol 1:33
    [Google Scholar]
  17. Hirsch M. S., Proffitt M. R., Tracy G. S., Black P. H. 1972; Age-dependent resistance to polyoma and murine sarcoma viruses in mice. J. Immunol 108:649
    [Google Scholar]
  18. Lind I. 1968; Non-specific adsorption of FITC-labelled serum globulins to Staph, aureus. Acta. path, microbiol. scandinav 73:624
    [Google Scholar]
  19. Lominski I., Arbuthnott J. P. 1962; Some characteristics of staphylococcus alpha haemolysin. J. Path. Bact 83:515
    [Google Scholar]
  20. Melish M. E., Glasgow L. A. 1970; The staphylococcal scalded-skin syndrome: development of an experimental model. New Engl. J. Med 282:1114
    [Google Scholar]
  21. Namavar F., De Graaff J., Verhoef J. 1976; Virulence of staphylococci (with special reference to experimental infection in neonatal mice and the phagocytosis by polymorphonuclear cells. In Staphylococci and staphylococcal diseases, edited by J. Jeljaszewicz. Stuttgart p 813
    [Google Scholar]
  22. Noble W. C. 1965; The production of subcutaneous staphylococcal skin lesions in mice. Br. J. exp. Path 46:254
    [Google Scholar]
  23. Postgate J. R. 1969; Viable counts and viability. In Methods in microbiology edited by Norris J. R., Ribbons D. W. London: vol 1: p 611
    [Google Scholar]
  24. Quie P. G., Greene W. H., Faville R. C., Hell H. R., Davis A. T. 1976; Recurrent staphylococcal infections associated with defective inflammatory response. In Staphylococci and staphylococcal diseases edited by Jeljaszewicz J. Stuttgart: p 907
    [Google Scholar]
  25. Reinarz A. B. G., Broome M. G., Sagik B. P. 1971; Age-dependent resistance of mice to sindbis virus infection: viral replication as a function of host age. Infect. Immun 3:268
    [Google Scholar]
  26. Sigel M. M. 1952; Influence of age on susceptibility to virus infections with particular reference to laboratory animals. Ann. Rev. Microbiol 6:247
    [Google Scholar]
  27. Takeuchi S., Suto T. 1974; Behaviour of Staph, aureus in skin tissue of mice. Jap. J. med. Sci. Biol 27:126
    [Google Scholar]
  28. Van der Vuver J. C. M., van Es-Boon M. M., Michel M. F. 1975; A study of virulence factors with induced mutants of Staphylococcus aureus. J. med. Microbiol. 8:279
    [Google Scholar]
  29. Woodin A. M. 1959; Fractionation of a leucocidin from Staphyloccus aureus. Biochem. J. 73:225
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/00222615-12-1-99
Loading
/content/journal/jmm/10.1099/00222615-12-1-99
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error