1887

Abstract

SUMMARY

Enterotoxigenic is a major cause of diarrhoea in man. When zinc in concentrations of 10 M or 10 M was added to the growth medium, there was a significant increase in heat-labile enterotoxin production by each of six toxigenic strains. Zinc in these concentrations did not alter bacterial growth or the activity of preformed toxin. Other heavy metals did not enhance toxin production and o-phenanthroline, a relatively specific zinc-chelating compound, blocked the enhancing effect. The significance of these findings is discussed in relation to the use of supplemental dietary zinc.

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/content/journal/jmm/10.1099/00222615-18-3-393
1984-12-01
2024-05-02
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References

  1. Chvapil M. 1976; Effect of zinc on cells and biomembranes.. Medical Clinics of North America 60:799–812
    [Google Scholar]
  2. Clements J. D., Flint D. C., Klipstein F. A. 1982; Immunological and physicochemical characterization of heat-labile enterotoxins isolated from two strains of Escherichia coli. Infection and Immunity 38:806–809
    [Google Scholar]
  3. Donta S. T., Moon H. W., Whipp S. C. 1974; Detection of heat-labile Escherichia coli enterotoxin with the use of adrenal cells in tissue culture.. Science 183:334–336
    [Google Scholar]
  4. Dupont H. L., Sullivan P., Evans D. G., Pickering L. K., Evans D. J., Volett J. J., Ericsson C. D., Ackerman P. B., Tioa W. S. 1980; Prevention of traveler’s diarrhea (emooriatric enteritis): prophylactic administration of subsalicylate bismuth.. Journal of the American Medical Association 243:237–241
    [Google Scholar]
  5. Failla M. L. 1977; Zinc: functions and transport in microorganisms. In Weinberg E. D. (ed) Microorganisms and minerals Marcel Dekker; New York: pp 151–214
    [Google Scholar]
  6. Falchuk K. H. 1977; Effect of acute disease and ACTH on serum zinc proteins.. New England Journal of Medicine 296:1129–1134
    [Google Scholar]
  7. Feeney R. E., Lightbody H. D., Garibaldi J. A. 1947; Zinc as an essential element for growth and subtilin formation by Bacillus subtilis. Archives of Biochemistry 15:13–17
    [Google Scholar]
  8. Jensen S. E., Campbell J. N. 1980; Nutritional factors controlling exocellular protease production by Pseudomonas aeruginosa. Journal of Bacteriology 144:844–847
    [Google Scholar]
  9. Kessler E., Israel M., Landshman N., Chechick A., Blumberg S. 1982; In vitro inhibition of Pseudomonas aeruginosa elastase by metal-chelating peptide derivatives.. Infection and Immunity 38:716–723
    [Google Scholar]
  10. Reynolds J. A., Schlesinger M. J. 1969; Alterations in the structure and function of Escherichia coli alkaline phosphatase due to Zn2+ binding.. Biochemistry 8:588–593
    [Google Scholar]
  11. Riddle L. M., Graham T. E., Amborski R. L. 1981; Medium for the accumulation of extracellular hemolysin and protease by Aeromonashydrophila. Infection and Immunity 33:728–733
    [Google Scholar]
  12. Riordan J. F. 1976; Biochemistry of zinc.. Medical Clinics of North America 60:661–674
    [Google Scholar]
  13. Sack R. B. 1980; Enterotoxigenic Escherichia coli:identification and characterization.. Journal of Infectious Diseases 142:279–286
    [Google Scholar]
  14. Sack D. A., Sack R. B. 1975; Test for enterotoxigenic Escherichia coli using Y1 adrenal cells in miniculture.. Infection and Immunity 11:334–336
    [Google Scholar]
  15. Sato H., Murata R. 1973; Role of zinc in the production of Clostridium perfringens alpha toxin.. Infection and Immunity 8:360–369
    [Google Scholar]
  16. Sato H., Yamakawa Y., Ito A., Murata R. 1978; Effect of zinc and calcium ions on the production of alpha-toxin and proteases by Clostridium perfringens. Infection and Immunity 20:325–333
    [Google Scholar]
  17. Sugarman B. 1983; Zinc and infection.. Reviews of Infectious Diseases 5:137–147
    [Google Scholar]
  18. Sugarman B., Eps L. R., Stenback W. A. 1982; Zinc and bacterial adherence.. Infection and Immunity 37:1191–1199
    [Google Scholar]
  19. Trotman C. N. A., Greenwood C. 1971; Effects of zinc and other metal ions on the stability and activity of Escherichia coli alkaline phosphatase.. Biochemical Journal 124:25–30
    [Google Scholar]
  20. Vallee B. L. 1959; Biochemistry, physiology and pathology of zinc.. Physiological Reviews 39:443–490
    [Google Scholar]
  21. Wegener W. S., Romano A. H. 1963; Zinc stimulation of RNA and protein synthesis in Rhizopusnigricans. Science 142:1669–1670
    [Google Scholar]
  22. Williams R. O., Loeb L. A. 1973; Zinc requirement for DNA replication in stimulated human lymphocytes.. Journal of Cell Biology 58:594–601
    [Google Scholar]
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