1887

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Volume 4, Issue 2

Induction Of Nasal Carriage Of Staphylococci In Mice And Its Relation To Hypersensitivity Free

Abstract

SUMMARY

Attempts were made to induce a carrier state in Swiss mice by intranasal inoculation of . A high mortality rate (90 per cent.) was observed when organisms were instilled intranasally, Aerosol infection also produced a high mortality (50 per cent.) and a rather low over-all carrier rate (30 per cent). When the organism was directly implanted with mild trauma (multiple puncture) on the nasal mucosa the mortality rate was reduced to 20 per cent. and nearly half of the initial animal population became nasal carriers of . A significant number (54.8 per cent.) of 685 mice treated by the multiple puncture method developed a delayed type of hypersensitivity to the test staphylococcus and the sensitisation effect was most evident among the carrier animals.

  • Received:
  • Accepted:
  • Published Online:
© J. MED. MICROBIOL. 1971
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1971-05-01
2024-04-30
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References

  1. Bassett H. F. M., Ferguson W. G., Hoffman E., Walton M., Blowers R., Conn Connie A. 1963; Sources of staphylococcal infection in surgical wound sepsis. J. Hyg., Camb 61:83
     [Google Scholar]
  2. Galbraith N. S. 1960; Symposium on carriers of penicillin-resistant staphylococci outside hospital. Staphylococcal infections in general practice. Proc. Roy. Soc. Med 53:253
     [Google Scholar]
  3. Gould J. C., Cruickshank J. D. 1957; Staphylococcal infection in general practice. Lancet 2:1157
     [Google Scholar]
  4. Henderson R. J., Williams R. E. O. 1961; Nasal disinfection in prevention of post-operative staphylococcal infection of wounds. Br. Med. J 2:330
     [Google Scholar]
  5. Johnson J. E. 3rd, Cluff L. E., Goshi K. 1961; Studies on the pathogenesis of staphylococcal infection. (1) The effect of repeated skin infection. J. Exp. Med 113:235
     [Google Scholar]
  6. Mcneill I. F., Porter I. A., Green C. A. 1961; Staphylococcal infection in surgical ward. A three-month study. Br. Med. J 2:798
     [Google Scholar]
  7. Panton P. N., Valentine F. C. O. 1929; Staphylococcal infection and re-infection. Br. J. Exp. Path 10:257
     [Google Scholar]
  8. Roodyn L. 1954; Staphylococcal infections in general practice. Br. Med. J 2:1322
     [Google Scholar]
  9. Simon H. J. 1960; Attenuated infection; the germ theory in contemporary perspective. Philadelphia and Montreal p 14
     [Google Scholar]
  10. Simon H. J. 1963; Epidemiology and pathogenesis of staphylococcal infection. 1. An experimentally induced attenuated staphylococcal infection in guinea pigs and its modification by tetracycline. J. Exp. Med 118:149
     [Google Scholar]
  11. Tulloch L. G., Alder V. G., Gillespie W. A. 1960; Treatment of chronic furunculosis. Br. Med. J 2:354
     [Google Scholar]
  12. Valentine F. C. O., Hall-Smith S. P. 1952; Superficial staphylococcal infection. Lancet 2:351
     [Google Scholar]
  13. Williams R. E. O., Jevons M. Patricia, Shooter R. A., Hunter C. J. W., Girling J. A., Griffiths J. D., Taylor G. W. 1959; Nasal staphylococci and sepsis in hospital patients. Br. Med. J 2:658
     [Google Scholar]
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Induction Of Nasal Carriage Of Staphylococci In Mice And Its Relation To Hypersensitivity
J. Med. Microbiol. 4, 195 (1971); https://doi.org/10.1099/00222615-4-2-195
/content/journal/jmm/10.1099/00222615-4-2-195
/content/journal/jmm/10.1099/00222615-4-2-195
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